摘要
胰岛素的口服给药一直是药剂学领域的研究热点。其核心问题是同时克服胰岛素口服吸收的多重屏障,提高胰岛素的口服生物利用度。纳米制剂技术的快速发展为实现胰岛素有效的口服递送提供了坚实的基础。该文综述胰岛素口服纳米粒的研究现状,围绕胰岛素口服吸收的多重屏障对这些纳米给药系统的优势和劣势进行讨论,并对纳米粒实现胰岛素口服递送的机遇和挑战进行了展望。
Oral delivery of insulin has always been a research highlight in the field of pharmaceutics.The key issue is to improve the bioavailability of orally delivered insulin by overcoming the multiple barriers to absorption of insulin simultaneously.Rapid breakthroughs in formulation technique of nanomedicine shed a light on effective oral delivery of insulin.In this publication,the current status of insulin-loaded nanoparticles was reviewed. The efficiency and shortcomings of insulin nanoparticles in overcoming the multiple barriers to absorption are discussed.The review ends with some prospects and challenges for the success of administering insulin-loaded nanoparticle orally in diabetes treatment.
作者
盛剑勇
杨晓宇
陈佶棠
彭天昊
杨祥良
SHENG Jianyong;YANG Xiaoyu;CHEN Jitang;PENG Tianhao;YANG Xiangliang(College of Life Science and Technology , Huazhong University of Science and Technology , Wuhan 430074, China;National Engineering Research Center for Nanomedicine ,Huazhong University of Science and Technlogy, Wuhan 430074, China)
出处
《医药导报》
CAS
北大核心
2018年第6期703-707,共5页
Herald of Medicine
基金
国家自然科学基金青年科学基金资助项目(81703443)
关键词
胰岛素
纳米粒
纳米载药系统
Insulin
Nanoparticles
Nanodrug delivery systems
