摘要
目的探讨同型半胱氨酸、超敏C反应蛋白及D-二聚体在诊断急性脑梗死患者中的应用价值。方法选取102例急性脑梗死患者作为观察组,另选取同时期本院接收的102例健康体检人群作为对照组,均测定同型半胱氨酸、超敏C反应蛋白及D-二聚体等各指标水平,并比较两组各指标水平、观察组不同梗死灶大小(A、B、C组)及不同神经功能缺损严重程度(轻度、重度、重度亚组)患者各指标水平。结果观察组同型半胱氨酸、超敏C反应蛋白、D-二聚体水平分别为(17.14±3.52)μmol/L、(10.24±4.05)mg/L、(558.34±226.45)μg/L,明显高于对照组的(10.52±2.03)μmol/L、(2.31±1.03)mg/L、(132.02±52.03)μg/L,差异有统计学意义(P<0.05)。观察组中C组各指标水平显著高于B组,差异有统计学意义(t=11.27、9.96、26.48,P<0.05);B组各指标显著高于A组,差异有统计学意义(t=14.02、7.78、7.60,P<0.05)。观察组中重度亚组患者各指标水平显著高于中度亚组,差异有统计学意义(t=8.11、6.38、28.85,P<0.05);中度亚组患者各指标水平显著高于轻度亚组,差异有统计学意义(t=6.40、4.47、16.07,P<0.05)。结论同型半胱氨酸、超敏C反应蛋白及D-二聚体在诊断急性脑梗死患者中的应用价值较高,可在诊断的基础上判断疾病发展程度,为治疗提供可靠依据,值得推广。
Objective To investigate the application value of homocysteine, high-sensitivity C-reactive protein and D-dimer in the diagnosis of acute cerebral infarction. Methods There were 102 acute cerebral infarction patients received from April 2016 to April 2017 as observation group, and concurrent 102 healthy people as control group. The levels of homocysteine, high sensitive C reactive protein and D-dimer were measured, and the levels of each index in the two groups, in different infarct size（group A, B, C） and different neurological deficit severity（moderate-server group, moderate group, mild group） in the observation group were compared. Results The observation group had homocysteine, high-sensitivity C-reactive protein and D-dimer respectively as（17.14±3.52） μmol/L,（10.24±4.05） mg/L and（558.34±226.45） μg/L, which were obviously higher than（10.52±2.03） μmol/L,（2.31±1.03） mg/L and（132.02±52.03） μg/L in the control group, and their difference was statistically significant（P〈0.05）. In observation group, group C had obviously higher each indicator level than group B, and the difference was statistically significant（t=11.27, 9.96, 26.48, P〈0.05）. Group B had obviously higher each indicator level than group A, and the difference was statistically significant（t=14.02, 7.78, 7.60, P〈0.05）. In the observation group, moderate-server group had obviously higher each indicator level than moderate group, and the difference was statistically significant（t=8.11, 6.38, 28.85, P〈0.05）. Moderate group had obviously higher each indicator level than mild group, and the difference was statistically significant（t=6.40, 4.47, 16.07, P〈0.05）. Conclusion Homocysteine, high-sensitivity C-reactive protein and D-dimer shows high application value in the diagnosis of acute cerebral infarction, and it can judge the severity of disease development on the basis of diagnosis and provide reliable basis for treatment. It is worth popularizing.
作者
周敏
谢梅
黎建
ZHOU Min;XIE Mei;LI Jian(Sichuan Neijiang Dongxing District Hospital of Traditional Chinese Medicine, Neijiang 641100, China)
出处
《中国实用医药》
2018年第17期9-11,共3页
China Practical Medicine
