摘要
自身免疫性肝炎(AIH)是一种由免疫介导的慢性进展性肝脏炎症性疾病,成人和儿童均可起病,女性患者居多。AIH以高血清IgG/γ-球蛋白血症、自身抗体阳性、界面性肝炎为主要特征,临床表现多样。近年AIH发病率逐年上升,如不及时治疗可进展为肝硬化、肝衰竭。免疫抑制治疗对AIH至关重要,可明显改善患者生存率。本文主要对AIH的诊治新进展作一概述。
Autoimmune hepatitis（ AIH） is a chronic progressive immune-mediated inflammatory liver disease. Both adults and children could be involved and women are more often affected. AIH is characterized by elevation of serum IgG/hypergammaglobulinemia,autoantibodies and interface hepatitis with diverse clinical spectrum. The incidence of AIH is increasing in recent years. If not treated timely,it may lead to cirrhosis and liver failure. Immunosuppressive therapy is crucial for improving patients＇ survival rate. This article summarized the advances in diagnosis and treatment of AIH.
作者
姜畔
王绮夏
马雄
JIANG Pan, WANG Qixia, MA Xiong(Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai Institute of Digestive Disease, Shanghai （200001）)
出处
《胃肠病学》
2018年第5期261-265,共5页
Chinese Journal of Gastroenterology
基金
国家自然科学基金国际合作与交流项目(81620108002)
国家自然科学基金面上项目(81771732
81570511
81770564)
上海市卫生计生系统优秀青年医学人才培养计划(2017YQ037)
上海市青年科技启明星计划(18QA1402700)
关键词
自身免疫性肝炎
免疫抑制剂
诊断
治疗
Autoimmune Hepatitis
Immunosuppressive Agents
Diagnosis
Therapy
