摘要
目的:探讨乌司他丁联合抗生素对急性重症肺炎患者全身炎症反应及应激激素分泌的影响。方法:选择2014年12月~2017年1月间本院治疗的78例急性重症肺炎患者,经随机数表法分为常规组、乌司他丁组,各39例。常规组接受常规抗生素治疗,乌司他丁组接受乌司他丁联合抗生素治疗,持续2周。对比两组患者治疗前后血清中急性时相蛋白、炎症因子、应激激素含量的差异。结果:治疗前,两组患者血清中急性时相蛋白、炎症因子、应激激素含量的差异无统计学意义(P>0.05)。治疗2周后,乌司他丁组患者血清中急性时相蛋白前白蛋白(PA)的含量高于常规组患者,C反应蛋白(CRP)的含量低于常规组患者;乌司他丁组患者血清中炎症因子白介素1β(IL-1β)、白介素-2(IL-2)、白介素-6(IL-6)的含量低于常规组患者;乌司他丁组患者血清中应激激素去甲肾上腺素(NE)、皮质醇(Cor)、血管紧张素Ⅱ(AngⅡ)含量低于常规组患者(P<0.05)。结论:乌司他丁联合抗生素治疗急性重症肺炎能够抑制全身炎症反应及应激反应。
Objective： To study the effect of ulinastatin combined with antibiotics on systemic inflammatory response and stress hormone secretion in patients with acute severe pneumonia. Methods： A total of 78 patients with acute severe pneumonia in our hospital between December 2014 and January 2017 were randomly divided into routine group and ulinastatin group, each with 39 cases. Routine group were treated with conventional antibiotics, and ulinastatin group were treated with ulinastatin and antibiotics; the treatments lasted for 2 weeks. The differences of serum acute phase proteins, inflammatory factors and stress hormones were compared between the two groups before and after treatment. Results： Before treatment, there were no significant differences in serum contents of acute phase proteins, inflammatory factors or stress hormones between the two groups （P〉0.05）. After 2 weeks of treatment, serum acute phase protein prealbumin （PA） content in ulinastatin group was higher than that in routine group whereas C-reactive protein （CRP） content was lower than that in routine group; serum inflammatory cytokines interleukin-1β （IL-1β）, interleukin-2 （IL-2） and interleukin-6 （IL-6） contents in ulinastatin group were lower than those in routine group; serum stress hormones NE, Cor and AngII contents in ulinastatin group were significantly lower than those in routine group （P〈0.05）. Conclusion： Ulinastatin combined with antibiotics for acute severe pneumonia can inhibit the systemic inflammatory response and stress response.
作者
沙静
杨晓宁
刘哲
SHA Jing;YANG Xiao-ning;LIU Zhe(Department of Internal Medicine,Ruikang Hospital,Yan＇an Automobile Transport Co.,Ltd.,Yan＇an,Shaanxi Province,716000,China;Department of Cardiology,Health Center of Yan＇an Yanchang Petroleum Co.,Ltd.,Baota Oil Production Plant,Yan＇an,Shaanxi Province,716000,China;Department of Cardiology,Affiliated Hospital of Yan＇an University,Yan＇an,Shaanxi Province,716000,China)
出处
《海南医学院学报》
CAS
2018年第9期911-914,共4页
Journal of Hainan Medical University
基金
陕西省科技计划项目(2010k15-03-02)~~
关键词
急性重症肺炎
乌司他丁
抗生素
全身炎症反应
应激激素
Acute severe pneumonia
Ulinastatin
Antibiotic
Systemic inflammatory response
Stress hormone
