摘要
目的探讨稳定型冠心病的危险因素及与中性粒细胞/淋巴细胞比值(NLR)的相关性。方法回顾性分析2016年1~12月新疆伊犁州友谊医院收治的因胸痛入院拟诊为冠心病的患者600例,依据患者冠状动脉造影结果,将其分为冠心病组(n=300)及对照组(n=300)。比较两组患者一般资料作疾病危险因素的单因素分析,采用二分类Logistic回归分析筛选疾病的危险因素,比较不同NLR水平患者Gensini评分,绘制ROC曲线分析NLR对疾病诊断的价值。结果冠心病组和对照组吸烟史、高血压史、糖尿病史、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、血红蛋白、白细胞及NLR比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,吸烟(OR=2.331,95%CI:1.590~4.505,P<0.05),LDL-C(OR=1.737,95%CI:1.327~2.274,P<0.05),NLR(OR=1.552,95%CI:1.230~3.329,P<0.05)是冠心病的独立危险因素,HDL-C(OR=0.456,95%CI:0.261~0.798,P<0.05)是冠心病的独立保护因素。不同NLR水平冠心病患者Gensini评分差异有统计学意义(P<0.05),NLR高者Gensini评分显著增高(P<0.05);ROC曲线显示NLR的曲线下面积为0.834(95%CI:0.802~0.867),NLR切值取2.5时,其诊断效率最高,敏感性为77.0%,特异性为80.7%。结论NLR可能是稳定型冠心病的一个较好预测指标。
Objective To study the risk factors of stable coronary heart disease and relationship between neutrophil-tolymphocyte ratio （NLR） and it.Methods From January to December 2016,in Yili Youyi Hospital,600 patients with chest pain and suspected as coronary heart disease were retrospectively analyzed.According to the results of coronary angiography,patients were divided into coronary heart disease （CAD） group （n =300） and control group （n =300）.Disease risk factors of general data in two groups were compared by single factor analysis,disease risk factors were screened by two classification Logistic regression analysis,the Gensini scores of patients with different NLR levels were compared,the value of NLR in the diagnosis of disease was analyzed by drawing ROC curve.Results The smoking history,hypertension history,diabetes history,low density lipoprotein cholesterol （LDL-C）,high density lipoprotein cholesterol （HDL-C）,hemoglobin,WBC and NLR in CAD group and control group were compared,the differences were statistically significant （P 〈 0.05）.Multivariate Logistic regression analysis showed that smoking （OR =2.331,95% CI：1.590-4.505,P 〈 0.05）,LDL-C （OR =1.737,95% CI：1.327-2.274,P 〈 0.05）,NLR （OR =1.552,95% CI：1.230-3.329,P 〈 0.05） were independent risk factor for CHD patients,and HDL-C （OR =0.456,95% CI：0.261-0.798,P 〈 0.05） was the independent protective factors for CAD patients.Gensini scores stratified in different NLR of CAD group were compared,the difference was statistically significant （P 〈 0.05）,Gensini scores was significantly higher in patients with higher NLR （P 〈 0.05）.ROC curve showed that the area under the curve was 0.834 （95% CI：0.802-0.867）,and when the NLR value was 2.5,the diagnosis efficiency was highest,the sensitivity was 77.0%,and the specificity was 80.7%.Conclusion NLR may be a good predictor of stable coronary heart disease.
作者
姜芸
吴莉
赵龙
JIANG Yun;WU Li;ZHAO Long(Ward Two Department of General Medicine, Tumor Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830011, China;Department of Cardiology, Yili Youyi Hospital, Xinjiang Uygur Autonomous Region, Yili 835000, China)
出处
《中国医药导报》
CAS
2018年第14期34-37,共4页
China Medical Herald
基金
新疆维吾尔自治区自然科学基金项目(2016D01C340)
