摘要
目的:比较磁共振FSE-IDEAL和IDEAL-IQ序列在定量测量水脂混合模型脂肪含量中的准确度和适用范围。方法:分别制作浓度范围为0%~100%、浓度梯度为10%的水脂溶液和浓度范围为2%~30%、浓度梯度为2%的脂肪乳溶液。采用FSE-IDEAL和IDEAL-IQ序列扫描水脂溶液和脂肪乳溶液模型,将FSE-IDEAL和IDEAL-IQ序列测得的脂肪分数与实际脂肪浓度进行比较。结果:(1)水脂溶液:FSE-IDEAL序列测得的脂肪分数与实际浓度差异无统计学意义(t=1.58,P=0.14);IDEAL-IQ序列测得的脂肪分数与实际脂肪浓度差异有统计学意义(t=-40.6,P<0.001)。FSE-IDEAL、IDEAL-IQ序列测得的脂肪分数与实际脂肪含量间均呈高度直线相关,相关系数分别为0.982和1。Bland-Altman散点图分析结果显示FSE-IDEAL序列测得的脂肪分数与实际浓度差值的95%置信区间为(-8.93%,-14.68%),IDEAL-IQ序列为(-4.76%,3.46%)。(2)仅对脂肪浓度≤70%的水脂溶液样本进行分析,两种序列的测量值与实际脂肪含量的相关系数均为1;Bland-Altman散点图分析结果显示FSE-IDEAL序列测得的脂肪分数与实际浓度差值的95%置信区间为(-1.16%,0.18%),IDEAL-IQ序列为(-4.83%,-3.41%)。(3)脂肪乳溶液:FSE-IDEAL、IDEAL IQ序列的脂肪测量结果与实际脂肪浓度差异均有统计学意义(t=2.842,P=0.013;t=21.363,P<0.001)。两种成像方法的测量值与实际脂肪含量的相关系数均为1,Bland-Altman散点图分析结果显示FSE-IDEAL序列测得的脂肪分数与实际浓度差值的95%置信区间为(-0.196%,-0.093%),IDEAL-IQ为(-2.076%,-0.990%)。结论:IDEAL-IQ和FSE-IDEAL在脂肪定量测量中与实际浓度均为高度直线相关,能满足临床测量脂肪含量的需要,两者各有优势,可根据不同需求合理选择脂肪分析序列。
Objective：To compare the accuracy and application range of FSE-IDEAL and IDEALIQ sequences in quantitative evaluation of fat content in water fat mixture model.Methods：A water fat mixed solution with a concentration range of 0%～100% and a concentration gradient of 10% and a fat emulsion with a concentration range of 2%～30% and a concentration gradient of 2% were respectively prepared.The samples were scanned with FSE-IDEAL and IDEAL-IQ sequences,respectively.FSEIDEAL-FaF and IDEAL-IQ-FaF were measured in the two sequences and compared with the actual fat concentration,respectively.Results：（1）For water-fat solution：there was no statistically significant difference between the whole sample of FSE-IDEAL-FaF and the actual fat concentration（t=1.58,P=0.14）;there was statistically significant difference between IDEAL-IQ-FaF and the actual fat concentration（t=-40.6,P〈0.001）.Values of these two sequences were highly linearly correlated with the actual fat content（R2 of 0.982 and 1,respectively）.Bland-Altman scatter plots were used to obtain the 95%confidence interval（CI）of the difference between the measured value and the actual value,respectively：FSE-IDEAL-FaF（-8.93%,-14.68%）,and IDEAL-IQ-FaF（-4.76%,3.46%）,respectively.（2）For water-fat solution samples（specific to fat concentration ≤70%）：the correlation coefficient of the results from the two sequences and the actual value of fat content of these two was 1.Bland-Altman scatter plots showed the 95% CI of the difference between the value acquired from FSEIDEAL and IDEAL-IQ sequence and the actual value was（-1.16%,-0.18%）and（-4.83%,-3.41%）,respectively.（3）For fat emulsion：FSE-IDEAL-FaF and IDEAL-IQ-FaF were significantly different from the actual fat concentration,respectively（t=2.842,P=0.013;and t=21.363,P〈0.001;respectively）.The correlation coefficient of the value from these two sequences and the actual value of fat content was 1.Bland-Altman scatter plots showed the 95% CI of the difference between the value acquired from FSE-IDEAL and IDEAL-IQ sequence and the actual value was（-0.196%,-0.093%）and（-2.076%,-0.990%）,respectively.Conclusions：The IDEAL-IQ and FSE-IDEAL are highly linearly correlated with the actual concentration in the fat quantitative measurement,which can meet the needs of the clinical measurement of fat content.Both sequences have their own advantages,and the fat analysis sequence can be selected reasonably according to different clinical demands.
作者
刘欢
王秋霞
盛晓兰
戴丽卉
彭成东
张菁
LIU Huan，WANG Qiu-xia，SHENG Xiao-lan(Department of Radiology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Chin)
出处
《放射学实践》
北大核心
2018年第5期442-447,共6页
Radiologic Practice
基金
国家自然科学基金项目(81771793
81301192)
湖北省自然科学基金项目(2017CKB900)
关键词
水脂溶液
脂肪定量
磁共振成像
对比研究
Water-fat solution
Fat quantification
Magnetic resonance imaging
Comparative study
