期刊文献+

骨保护素基因多态性与心血管疾病易患性关系的荟萃分析 被引量:1

A meta-analysis on the association between genetic polymorphisms of osteoprotegerin and cardiovascular disease
原文传递
导出
摘要 目的应用荟萃分析探讨骨保护素基因rs2073617T/C(950T/C)和rs2073618G/C(1181G/C)位点基因多态性与心血管疾病易患性的关系。方法应用计算机检索并辅以手工检索,纳入从建库至2017年2月28日中国知网、中国生物医学文献数据库、万方数据库、中国期刊全文数据库、Embase、PubMed和Cochrane Library中关于骨保护素基因rs2073617T/C和rs2073618G/C位点基因多态性与心血管疾病遗传关联性的观察性研究。采用Newcastle-Ottawa Scale(NOS)评分系统评价纳入研究的质量,采用STATA 12.0软件进行数据分析。结果纳入了临床病例对照研究11项,包含心血管疾病患者2 115例和健康对照者1 467名。荟萃分析表明,骨保护素基因rs2073617T/C和rs2073618G/C位点基因多态性与心血管疾病易患性相关(rs2073617T/C等位基因模型:OR=0.79,95%CI 0.73-0.87,P=0.001;rs2073618G/C等位基因模型:OR=0.83,95%CI 0.74-0.92,P=0.001)。骨保护素基因rs2073617T/C和rs2073618G/C位点基因多态性与冠心病和急性冠状动脉综合征发病均相关(冠心病等位基因模型: OR=0.83, 95%CI 0.75-0.92,P=0.001;急性冠状动脉综合征等位基因模型:OR=0.73,95%CI 0.62-0.85,P〈0.001)。这两个位点的基因多态性与冠状动脉病变支数均无相关性(rs2073617T/C等位基因模型:OR=1.00,95%CI 0.81-1.24,P=0.985;rs2073618G/C等位基因模型:OR=0.98,95%CI 0.80-1.21,P=0.626)。应用限制性片段长度多态性聚合酶链反应(PCR-RFLP)和聚合酶链反应-连接酶检测反应(PCR-LDR)方法发现骨保护素基因多态性与心血管疾病关联(等位基因模型:OR=0.79,95%CI 0.72-0.86,P〈0.001),而荧光定量微测序法和分子探针技术未发现骨保护素基因多态性与心血管疾病关联(等位基因模型:OR=0.86,95%CI 0.65-1.12,P=0.263)。结论荟萃分析表明,骨保护素基因rs2073617T/C与rs2073618G/C位点基因多态性可能与心血管疾病易患性相关。 Objective To explore the association between genetic polymorphisms of rs2073617T/C (950T/C) and rs2073618G/C(1181G/C) in the osteoprotegerin gene and cardiovascular disease with meta-analysis. Methods A computer-based search for the study of relationship between genetic polymorphisms of rs2073617T/C and rs2073618G/C in the osteoprotegerin gene and cardiovascular disease were performed in electronic databases including China National Knowledge Infrastructure(CNKI), China Biomedical Literature Database, Wanfang Database, Chinese Journal Full-text Database, Embase, PubMed, and Cochrane Library, supplemented by manual search, from the beginning of library to February 28, 2017. The quality of the included studies were assessed by the Newcastle-Ottawa Scale (NOS) scoring system. Data were analyzed using STATA 12.0 software. Results Eleven clinical case-control studies that enrolled 2 115 patients with cardiovascular disease and 1 467 healthy subjects were included.The results indicated that osteoprotegerin gene polymorphisms of rs2073617T/C and rs2073618G/C might be closely associated with the susceptibility to cardiovascular disease(rs2073617T/C allele model: OR=0.79, 95%CI 0.73 - 0.87, P=0.001;rs2073618G/C M allele and W allele: OR=0.83, 95%CI 0.74 - 0.92, P=0.001). The osteoprotegerin gene polymorphisms of rs2073617T/C and rs2073618G/C were significantly related to the incidence of coronary artery disease and acute coronary syndrome(coronary artery disease allele model: OR=0.83, 95%CI 0.75 - 0.92,P=0.001 ;acute coronary syndrome allele model: 0R=0.73,95%CI 0.62 - 0.85, P〈0.001). However, there was no significant correlation between the genetic polymorphisms of these two sites and the lesion vessel number of coronary artery (rs2073617T/C allele model: OR= 1.00,95%CI 0.81 - 1.24, P=0.985;rs2073618G/C allele model: OR= 0.98, 95%C1 0.80 - 1.21, P=0.626). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and polymerase chain reaction-ligase detection reaction(PCR-LDR) evidenced the association between osteoprotegerin gene polymorphisms and cardiovascular disease(allele model: OR=0.79, 95%CI 0.72 - 0.86, P〈0.O01), but no obvious relationship was found with fluorogenic quantitative detection and molecularprobc(allele model: OR=0.86, 95%C1 0.65 - 1.12, P=0.263). Conclusion This recta-analysis indicates that the osteoprotegerin gene polymorphisms of rs2073617T/C and rs2073618G/C may be closely related to the increased risk of cardiovascular disease.
作者 信佳言 丛洪良 Xin Jiayan;Cong Hongliang(Graduate School of Tianjin Medical University, Tianjin 300070, Chin)
出处 《中华心血管病杂志》 CAS CSCD 北大核心 2018年第6期485-492,共8页 Chinese Journal of Cardiology
关键词 骨保护素 多态性 单核苷酸 心血管疾病 META分析 Osteoprotegerin Polymorphism single nucleotide Cardiovascular diseases Meta-analysis
  • 相关文献

参考文献6

二级参考文献65

  • 1罗助荣,张克己,郑磊磊,徐高阳,谢菁菁,林毅,盖晓波.血清骨保护素、可溶性核因子κB受体活化因子配体与急性冠状动脉综合征相关性研究[J].中华临床医师杂志(电子版),2011,5(10):2886-2889. 被引量:8
  • 2谢钦菁,罗助荣.骨保护素作为预测心血管疾病发病率和死亡率的新标志物的研究进展[J].中华临床医师杂志(电子版),2011,5(10):2963-2966. 被引量:5
  • 3尚玉红,洪秀芳,吴鹏,马合木达.冠心病中医辨证与QT和JT离散度的关系[J].中国中西医结合急救杂志,2005,12(2):87-90. 被引量:17
  • 4柯元南,陈纪林.不稳定性心绞痛和非ST段抬高心肌梗死诊断与治疗指南[J].中华心血管病杂志,2007,35(4):295-304. 被引量:2149
  • 5Rhee EJ, Oh KW, Jung CH, et al. The relationship between four single nucleotide polymorphisms in the promoter region of the osteoprotegerin gene and aortic calcification or coronary artery disease in Koreans. Clin Endocrinol (Oxf), 2006,64:689-697.
  • 6Soufi M, Schoppet M, Sattler AM, et al. Osteoprotegerin gene polymorphisms in men with coronary artery disease. J Clin Endocrinol Metab, 2004,89 : 3764-3768.
  • 7Kaden JJ, Bickelhaupt S, Grobholz R, et al. Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulate aortic valve calcification. J Mol Cell Cardiol, 2004,36:57-66.
  • 8Rasmussen LM, Tarnow L, Hansen TK, et al. Plasma osteoprotegerin levels are associated with glycaemic status, systolic blood pressure, kidney function and cardiovascular morbidity in type 1 diabetic patients. Eur J Endocrinol, 2006,154:75-81.
  • 9Anand DV, Lahiri A, Lim E, et al. The relationship between plasma osteoprotegerin levels and coronary artery calcification in uncomplicated type 2 diabetic subjects. J Am Coll Cardiol, 2006, 47: 1850-1857.
  • 10Xiang GD, Xu L, Zhao LS, et al. The relationship between plasma osteoprotegerin and endothelium-dependent arterial dilation in type 2 diabetes. Diabetes, 2006,55 : 2126-2131.

共引文献13

同被引文献17

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部