摘要
目的探讨单唾液酸四己糖神经节苷脂(GM1)联合小剂量强的松治疗成人难治性癫痫的疗效和认知功能的影响。方法将50例成人难治性癫痫患者随机分成对照组和治疗组各25例。对照组给予常规抗癫痫药物治疗,治疗组使用在抗癫痫药物治疗基础上,使用GM1联合小剂量强的松治疗,18周后比较2组患者的疗效,并进行智力、记忆商测定。结果治疗组有效率为80%,显著优于对照组(56%),差异有统计学意义(P<0.05);操作智商、语言智商、总智商与记忆商评分,治疗前后比较,治疗组均显著高于对照组,差异有统计学意义(P<0.05)。结论 GM1联合小剂量强的松治疗成人难治性癫痫患者,可改善患者认知功能,提高疗效。
Objective To evaluate the curative effect of Monosialotetrahexosyl ganglioside（ GM1） and low-dose prednisone in treating adults patients with refractory epilepsy cured by,as well as to assess the impact on the patient＇s cognitive function.Methods Fifty adult patients with refractory epilepsy were equally divided into two groups： control group and treatment group. The control group was cured by the conventional antiepileptic drugs. On the basis of taking the above drugs,the treatment group was cured by GM1 and low-dose prednisone.After 18 weeks,we compared the curative effect and assessed the intelligence,memory quotient of two groups.Results The markedly effective rate of treatment group was 80%,higher than the rate of control group（ 56%）.The difference was statistically significant（ P〈0. 05）. Compared with those of the control group,the scores of operation IQ,language IQ,memory quotient and total intelligence of treatment group were higher after therapy.The difference was statistically significant（ P〈0. 05）. Conclusions The GM1 and low-dose prednisone may enhance the cognitive function of adult patients with refractory epilepsy and improve the curative effect.
作者
李叶娥
郑书恭
陈飞燕
谢玉纯
LI Ye-e(Department of Neurology, Dalang hospital of Dongguan, Dongguan, Guangdong,523770, Chin)
出处
《齐齐哈尔医学院学报》
2018年第5期508-510,共3页
Journal of Qiqihar Medical University
基金
东莞市医疗卫生单位科技计划一般项目(2015105101058)
