摘要
综合分析小剂量电离辐射对职业人群血细胞的影响,为职业防护措施提供依据。通过检索国内外数据库,查找相关文献,运用Stata12.0软件进行Meta分析。结果显示:辐射暴露组人群白细胞和血小板计数异常,危险性高于未暴露组,比值比(Odds ratio,OR)及95%可信区间(Confidence interval,CI)分别为2.282(1.845,2.821)和1.753(1.348,2.280);红细胞计数异常则未见统计学意义。工龄长短亚组分析显示:工龄越长,白细胞与血小板计数异常危险性越高(p<0.05),红细胞则越低(p>0.05)。按工种对白细胞进行亚组分析结果显示:医用X射线、介入放射、放射治疗、核医学、工业探伤均能增加白细胞异常危险性,影响最大的为核医学[OR=5.288,95%CI(1.759,15.892)],影响最小的为医用X射线[OR=1.988,95%CI(1.178,3.356)]。提示小剂量电离辐射可增加职业暴露人群白细胞和血小板异常检出率,对红细胞则未见明显影响。
This study examines the effects of low-dose ionizing radiation on peripheral hemocytes of the occupational population, and provides evidence for occupational protective measures. Electronic databases were searched for the relevant studies. A meta-analysis was performed using Stata12.0 software. The results indicated an increased risk of abnormal leukocyte and platelet count in radiation workers compared with that in nonradiation workers, with the combined odds ratio（OR） and 95% confidence interval（CI） = 2.282（1.845, 2.821） and 1.753（1.348, 2.280）, respectively, for the two groups. However, no statistically significant difference was observed in case of abnormal erythrocyte count. The subgroup analysis indicated an increase in the risk of abnormal leukocyte and platelet count（p〈0.05） with an increase in duration of service. In comparison, the increase in risk of abnormal erythrocyte count（p〉0.05） was lower. Furthermore, the subgroup analysis, taking into account the type of work engaged in, revealed an increase in the abnormal leukocyte count for workers working with medical X-rays, interventional radiology, radiotherapy, nuclear medicine, and industrial inspection. Radiation workers involved in nuclear medicine were observed to be one of the most affected groups [OR=5.288, 95% CI（1.759, 15.892）], while those working with medical X-rays were relatively less affected [OR=1.988, 95% CI（1.178, 3.356）]. Our studies suggest that while low-dose ionizing radiation can increase the abnormal leukocyte and platelet count in radiation workers, it does not have a significant effect on the abnormal erythrocyte count.
作者
王雷
钟媛
何明艳
黄波
让蔚清
WANG Lei;ZHONG Yuan;HE Mingyan;HUANG Bo;RANG Weiqing(School of Public Health, University of South China, Hengyang 421001, China)
出处
《辐射研究与辐射工艺学报》
CAS
CSCD
2018年第3期42-51,共10页
Journal of Radiation Research and Radiation Processing
基金
国家自然科学基金(81673107)
湖南省教育厅科学研究重点项目(16A185)
"疾病控制评价研究中心"南华大学重点实验室经费项目(NHSYS04)资助~~
关键词
电离辐射
职业暴露
血细胞
META分析
Ionizing radiation
Occupational exposure
Hemocyte
Meta analysis
