摘要
目的：研究大黄-甘草药对的中医方剂用量、配比与方剂功效的关系。方法：从中医方剂数据库中检索组成含甘草、大黄的方剂共2361首,利用计算机算法将方剂文本信息整理为表格形式,统计方剂中甘草和大黄的用药量、配伍比例及方剂功效,用Apriori算法及网络图对三者间关系进行挖掘分析。结果：大黄常用剂量在25.16~35.16g,甘草常用剂量在0~5.16g,15.16~35.16g;常用配伍比例为1/1,占总数的37.85%;方剂功效以止痛、清热、利水渗湿、消肿散结、解毒为主,且剂量、配比与功效存在相关关系。结论：应用Apriori算法及网络关联分析等数据分析方法可发现药对组成规律,为方剂配伍应用研究提供新的方法,为临床组方用药及新药研发提供理论依据。
Objective： To study on the relationship of herb pair of Rhei Radix et Rhizoma-Glycyrrhizae Radix et Rhizoma in dosage,ratio and efficacy. Method： Totally 2 361 prescriptions containing Rhei Radix et Rhizoma-Glycyrrhizae Radix et Rhizoma from traditional Chinese medicine（ TCM） prescription database were retrieved by computerized algorithm. Statistics were made for the doses of Rhei Radix et Rhizoma and Glycyrrhizae Radix et Rhizoma,the ratio of their dosage and the efficacy. Mining analysis was made for the relationship between them through Apriori algorithm. Result： Rhei Radix et Rhizoma was often used at doses between 25. 16-35. 16 g,Glycyrrhizae Radix et Rhizoma was commonly used at doses between 0-5. 16 g,15. 16-35. 16 g. The commonest use ratio was 1/1,accounting for 37. 85%. These prescriptions can clear heat,relieve pain,clear damp and promote diuresis,disperse swelling and dissipate binds,and relieve internal heat or fever. The efficacy has a high correlation with the dosage and ratio. Conclusion： Apriori algorithm and other data analysis methods can be applied to find the application regularity of the herb pairs,and provide a new method for study on prescription compatibility,as well as a basis for clinical application and new drug development.
作者
曹玉洁
陈艳琰
唐于平
金益
沈娟
康安
周桂生
尚尔鑫
段金廒
CAO Yu-jie;CHEN Yan-yan;TANG Yu-ping;JIN Yi;SHEN Juan;KANG An;ZHOU Gui-sheng;SHANG Er-xin;DUAN Jin-ao(College of Pharmacy, Shaanxi University of Chinese Medicine, Xi＇an 712046, China;Jiangsu Provincial Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of Traditional Chinese Medicine Formulae, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2018年第14期182-187,共6页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家重点基础研究发展计划(973计划)项目(2011CB505300,2011CB505303)
关键词
大黄
甘草
药对
APRIORI算法
网络关联
Rhei Radix et Rhizoma
Glycyrrhizae Radix et Rhizoma
herb pair
Apriori algorithm
network association
