摘要
目的观察温针灸结合超短波治疗膝骨性关节炎(KOA)的疗效,比较治疗前后KOA患者血清中肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)的水平表达,探讨温针灸结合超短波治疗KOA的作用机理。方法将80例KOA患者分为实验组(温针灸结合超短波)和对照组(超短波)2组,各40例,各组每天均治疗1次,10次为1个疗程,共治疗2个疗程。采用膝关节骨性关节炎自评量表(WOMAC)评估2组患者治疗前后疗效,用双抗体夹心酶联免疫吸附法(ELISA)检测患者血清中TNF-α、IL-6水平的变化情况。结果实验组治疗后总有效率(97.5%)显著高于对照组(87.5%),2组比较差异有统计学意义(P<0.05)。实验组治疗后疼痛、僵硬、日常活动困难度各项评分比治疗前明显降低,差异具有统计学意义(P<0.05)。2个疗程治疗后,实验组WOMAC各项评分明显低于对照组,差异有统计学意义(P<0.05)。实验组治疗后TNF-α、IL-6水平低于治疗前(P<0.05),且明显低于对照组(P<0.05)。结论温针灸结合超短波治疗KOA临床疗效显著,其作用机制的发挥可能与降低KOA患者血清中TNF-α、IL-6的表达水平有关。
Objective To observe the therapeutic effect of warm acupuncture combined with ultrashort wave on the treatment of knee osteoarthritis（ KOA）,and to compare the levels of tumor necrosis factor-α（ TNF-α） and interleukin-6（ IL-6） in serum of KOA patients before and after treatment,and to explore the mechanism of warm acupuncture combined with ultrashort wave in the treatment of KOA. Methods 80 patients with KOA were randomly divided into the experimental group（ warm acupuncture combined with ultrashort wave） and the control group（ ultrashort wave）,40 cases in each group,treated once a day,10 times for a course of treatment,total treatment of 2 courses. Western Ontario and me-master university osteoarthritis index（ WOMAC） was used to evaluate the curative effect before and after treatment. The peripheral serum of the two groups before and after treatment were collected and the serum TNF-α,IL-6 were measured by double antibody sandwich enzyme-linked immunosorbent assay（ ELISA）. Results The total effective rate was 97. 5% in the experimental groups,which was significantly higher than that in the control group 87. 5%（ P 〈0. 05）; Compared with treatment before,the scores of pain,stiffness and daily activities were lower than those before treatment（ P〈 0. 05）. After treatment,the scores of WOMAC in the experimental group were significantly lower than those in the control group,the difference were statistically significant（ P〈 0. 05）. The level of TNF-α and IL-6 in the experimental group were lower than that in the control group（ P〈 0. 05）,and the level after treatment was lower than that of the control group（ P 〈0. 05）. Conclusion The clinical efficacy of Warming Acupuncture combined with ultrashort wave in the treatment of KOA is significant,which reduces the expression of TNF-α and IL-6 in serum of KOA patients,and it may be one of the mechanisms of its role in the treatment of KOA.
作者
张艳玲
马晓秀
李春
刘君伟
武永利
ZHANG Yanling;MA Xiaoxiu;LI Chun;LIU Junwei;WU Yongli(Orthopedics Department of Traditional Chinese Medicine, General Hospital of Ningxia Medical University, Yinehuan 75004, China;Rehabilitation Department of Traditional Chinese Medicine, General Hospital of Ningxia Medical University, Yinchuan 75004, China;Ningxia Medical University, Yinchuan 75004, China)
出处
《宁夏医学杂志》
CAS
2018年第5期403-405,共3页
Ningxia Medical Journal
基金
宁夏医科大学校级课题(XM2015100)
关键词
温针灸
超短波
膝骨性关节炎
细胞因子
Warming acupuncture
Ultrashort wave
Knee osteoarthritis
Cytokines
