摘要
目的探讨妊娠期妇女甲状腺功能代谢与母婴预后的关系,为改善母婴预后提供参考依据。方法选取404例孕妇作为研究对象,按照甲状腺功能筛查结果分为亚甲状腺功能减退症(简称亚甲减)组(n=36)、甲减组(n=11)、甲状腺功能亢进症(简称甲亢)组(n=16)、低甲状腺素(TH)血症组(n=24)和甲状腺功能代谢正常组(n=317)。比较各组孕妇母婴预后。结果低TH血症组、亚甲减组、甲减组和甲亢组引产率、自然流产率、早产率、产钳助产率均明显高于正常组,顺产率及剖宫产率均明显低于正常组,差异均有统计学意义(P<0.05);甲减组、甲亢组新生儿体质量及新生儿5、10min Apgar评分均明显低于低TH血症组、亚甲减组和正常组,差异均有统计学意义(P<0.05);低TH血症组、甲减组、甲亢组妊娠期高血压综合征、妊娠期糖尿病、胎儿生长受限发生率均明显高于正常组和亚甲减组;甲减组、甲亢组低体质量儿发生率明显高于正常组、低TH血症组和亚甲减组,亚甲减组、甲减组、甲亢组胎儿宫内窘迫发生率明显高于正常组、低于TH血症组,差异均有统计学意义(P<0.05)。结论妊娠期妇女甲状腺功能代谢异常对母婴预后有明显影响,增加了不良母婴预后的发生率,应给予早期筛查及干预,以改善母婴预后。
Objective To investigate the relationship between hyroid function metabolism and maternal and neonatal prognosis in pregnant women ,and to provide reference for improving maternal and neonatal progno-sis .Methods A total of 404 pregnant women were selected as the subjects .According to the thyroid function screening results they were divided into hyperthyroidism group （n=16） ,hypothyreosis group （n=11） ,sub-clinical hypothyreosis group （n=36） ,low thyroxine （TH） group （n=24） and normal group （n=317） .The maternal prognosis of each group was compared .Results The induction rate ,spontaneous abortion rate ,pre-term birth rate ,and forceps delivery rate were significantly higher in lower TH group ,subsubtract group ,hy-pothyroidism group ,hypothyroidism group and hyperthyroidism group than those in normal group ,the rate of spontaneous delivery and cesarean section were significantly lower than those of the normal group （P〈0 .05）;the body mass and the new born 5 ,10 min Apgar scores in the hypothyroidism group and the hyperthyroidism group were significantly lower than those in hypothyroidemia group ,subsubtraction group and normal group （P〈0 .05） .The incidence of pregnancy induced hypertension syndrome ,gestational diabetes and fetal growth restriction in hypothyroidism group ,hypothyroidism group and hyperthyroidism group were significantly high-er than those of normal group and subsubtraction group ,the incidence of low-birth-weight infants in hypothy-roidism group and hyperthyroidism group was significantly higher than that in normal group ,hypothyroidemia group and subsubtract group .The incidence of fetal distress in subsubtract ,hypothyroidism ,hyperthyroidism and hyperthyroidism group was significantly higher than that of the normal group and lower than the T H group （P〈0 .05） .Conclusion The abnormal metabolism of thyroid function in pregnant women has a significant im-pact on the prognosis of mother and infant ,w hich increases the incidence of adverse maternal and neonatal prognosis . Early screening and intervention should be given to improve the prognosis of mothers and infants .
作者
罗朝阳
王婷婷
陈蓉
曹平
LUO Chaoyang;WANG Tingting;CHEN Rong;CAO Ping(Department of Endocrinology, the Second People＇s Hospital of Jingmen ,Jingmen, Hubei 448001 , China)
出处
《检验医学与临床》
CAS
2018年第11期1559-1561,1565,共4页
Laboratory Medicine and Clinic
基金
2014年度荆门市科技计划重点项目[(2014)7号]
关键词
甲状腺功能
妊娠期
母婴预后
thyroid function
pregnant
maternal prognosis
