摘要
目的探究严重瓣膜病合并心房颤动患者心脏手术中应用左西孟旦联合多巴胺的临床作用。方法将我院96例严重瓣膜病合并心房颤动患者随机分为单一组(48例,左西孟旦)与联合组(48例,左西孟旦+多巴胺)。比较两组手术前、后肌酸激酶同工酶(CK-MB)、脑钠肽(BNP)、心肌肌钙蛋白I(cTnI)水平、主动脉阻断时间、拔管时间、住院时间及不良反应发生情况。结果术后两组CK-MB、BNP、cTnI水平均升高,且联合组显著低于单一组(P<0.05);联合组拔管时间、住院时间显著短于单一组(P<0.05);两组不良反应总发生率差异不显著(P>0.05)。结论严重瓣膜病合并心房颤动患者心脏手术中应用左西孟旦联合多巴胺可保护患者心肌功能,加快恢复速度,且不会明显增加不良反应。
Objective To investigate the clinical effect of levosimendan combined with dopamine in cardiac surgery in patients with severe valvular disease complicated with atrial fibrillation. Methods A total of 96 patients with severe valvular disease complicated with atrial fibrillation in our hospital were randomly divided into single group （n=48, levosimendan） and combined group （n=48, levosimendan＋dopamine）. The preoperative and postoperative creatine kinase isoenzyme （CKMB）, brain natriuretic peptide （BNP）, cardiac troponin I （cTnI） levels, aortic occlusion time, extubation time, hospital stays and total incidences of adverse reactions were compared in the two groups. Results After surgery, the CK-MB、BNP、cTnI levels increased in the two groups, of which the combined group were significantly lower than those in the single group （P〈0.05）. The extubation time and hospital stays in the combined group were significantly shorter than those in the single group （P〈0.05）. There was no significant difference in total incidences of adverse reactions between the two groups （P〉0.05）. Conclusion The application of levosimendan combined with dopamine in cardiac surgery in patients with severe valvular disease and atrial fibrillation can protect myocardial function, speed up recovery, and it will not significantly increase adverse reactions.
作者
赵龙
ZHAO Long(Baoji Central Hospital,Baoji 721008,China)
出处
《临床医学研究与实践》
2018年第15期22-23,共2页
Clinical Research and Practice
关键词
左西孟旦
多巴胺
瓣膜病
心房颤动
levosimendan
dopamine
valvular heart disease
atrial fibrillation
