摘要
Hairpin pyrrole-imidazole(Py-Im) polyamides are a class of programmable minor-groove binders that recognize pre-determined DNA double helixes with high affinity and specificity. They are capable of regulating gene expression by modulating the activity of transcription factors. To date, Py-Im polyamides have been successfully applied as a potent tool to disturb DNA functions and considered as a group of promising candidates for the clinical applications. Herein, this review will focus on summarizing the recent advances of Py-Im polyamides from their synthesis to applications via various modifications at the molecular level.
Hairpin pyrrole-imidazole(Py-Im) polyamides are a class of programmable minor-groove binders that recognize pre-determined DNA double helixes with high affinity and specificity. They are capable of regulating gene expression by modulating the activity of transcription factors. To date, Py-Im polyamides have been successfully applied as a potent tool to disturb DNA functions and considered as a group of promising candidates for the clinical applications. Herein, this review will focus on summarizing the recent advances of Py-Im polyamides from their synthesis to applications via various modifications at the molecular level.
基金
supported by the Shenzhen Sciences & Technology Innovation Council (Nos. GJHS20170314154409805, GJHS20160331195142827, GJHS20150417103343317, JCYJ201708 1815358196, JCYJ20150401150223649 and JCYJ20170413165 916608)
the National Natural Science Foundation of China (Nos. 21672254, 21778068, 21502219 and 21432003)
