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文拉法辛联合低剂量氨磺必利治疗重度抑郁症的临床效果及安全性 被引量:5

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摘要 目的探讨文拉法辛联合低剂量氨磺必利治疗重度抑郁症的临床效果与安全性。方法选取2015年7月12日至2017年10月5日收治的重度抑郁症患者108例作为研究对象,分为对照组与观察组,每组54例。对照组仅应用文拉法辛治疗;观察组采用文拉法辛联合低剂量氨磺必利治疗,比较两组患者的临床疗效、用药不良反应与血清白细胞介素-18(IL-18)水平。结果观察组治疗总有效率为96.3%,高于对照组的83.3%,差异有统计学意义(P<0.05)。观察组患者用药后出现头晕、口干各1例,不良反应发生率为3.7%;对照组患者用药后出现头晕4例、口干3例、便秘5例,不良反应发生率为22.2%,两组不良反应发生率差异有统计学意义(P<0.05)。治疗前,观察组、对照组的IL-18分别为(249±34)ng/L、(250±30)ng/L,差异无统计学意义(P>0.05);治疗7 d、14 d、1个月、2个月后,观察组患者的IL-18水平明显低于对照组,差异有统计学意义(P<0.05)。结论采用文拉法辛联合低剂量氨磺必利治疗重度抑郁症患者临床效果确切,且安全性高,无明显不良反应。
作者 张恩旭
出处 《中国药物经济学》 2018年第6期58-60,共3页 China Journal of Pharmaceutical Economics
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