摘要
目的探讨丹莪妇康煎膏联合醋酸亮丙瑞林微球治疗复发性子宫内膜异位症的临床疗效。方法选取2016年3月—2017年9月在首都医科大学附属北京妇产医院治疗的复发性子宫内膜异位症患者78例,根据用药差别分为对照组(39例)和治疗组(39例)。对照组患者腹部皮下注射注射用醋酸亮丙瑞林缓释微球,月经周期第1天给药,3.75 mg/次,1次/4周;治疗组在对照组基础上于月经开始前10 d口服丹莪妇康煎膏,15 g/次,2次/d。两组患者均经过12周治疗。评价两组患者临床疗效,同时比较治疗前后两组子宫内膜厚度、Kupperman和视觉模拟评分(VAS)及性激素水平和血清学指标。结果治疗后,对照组临床有效率为79.50%,显著低于治疗组的94.87%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者子宫内膜厚度显著缩小(P<0.05),Kupperman评分和VAS明显降低(P<0.05);且治疗组子宫内膜厚度、Kupperman和VAS评分均明显小于对照组(P<0.05)。治疗后,两组患者血清促卵泡成熟激素(FSH)、黄体生成激素(LH)、雌二醇(E2)水平明显下降(P<0.05);且治疗组患者性激素水平明显低于对照组(P<0.05)。治疗后,两组血清CA125、抗子宫内膜抗体(EMAb)水平均显著降低(P<0.05);且治疗组CA125和EMAb水平明显低于对照组(P<0.05)。结论丹莪妇康煎膏联合醋酸亮丙瑞林微球治疗复发性子宫内膜异位症可有效改善患者绝经症状和疼痛,调节机体性激素水平,降低血清CA125、EMAb含量。
Objective To investigate the clinical efficacy of Dan＇e Fukang Soft Extracts combined with leuprolide acetate microspheres in treatment of recurrent endometriosis. Methods Patients（78 cases） with recurrent endometriosis in Beijing Obstetrics and Gynecology Hospital, Capital Medical University from March 2016 to September 2017 were divided into control（39 cases） and treatment（39 cases） group based on different treatment. Patients in the control group were abdominal subcutaneous injection administered with Leuprorelin Acetate Microspheres Sustained Release for injection on the first day of menstruation, 3.75 mg/time, once every 4 weeks. Patients in the treatment group were po administered with Dan＇e Fukang Soft Extracts on the basis of the control group 10 d before menstruation, 15 g/time, twice daily. Patients in two groups were treated for 12 weeks. After treatment, the clincial efficacies were evaluated, and the endometrial thickness, Kupperman and VAS scores, the sex hormone levels, the serological indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 79.50%, which was significantly lower than 94.87% in the treatment group, and there were differences between two groups（P〈0.05）. After treatment, the thickness of the endometrium in two groups was significantly reduced（P〈0.05）, Kupperman and VAS was significantly decreased（P〈0.05）. And the thickness of the endometrium, Kupperman and VAS in the treatment group after treatment was significantly lower than that in the control group（P〈0.05）. After treatment, the FSH, LH and E2 levels in two groups were significantly decreased（P〈0.05）, and the sex hormone levels in the treatment group after treatment were significantly lower than those in the control group（P〈0.05）. After treatment, the CA125 and EMAb levels in two groups were significantly decreased（P〈0.05）, and the CA125 and EMAb levels in the treatment group after treatment were significantly lower than those in the control group（P〈0.05）. Conclusion Dan＇e Fukang Soft Extracts combined with leuprolide acetate microspheres in treatment of recurrent endometriosis can effectively improve the menopausal symptoms and pain, sex hormone and decrease the CA125 and EMAb levels.
作者
张佟
叶红
ZHANG Tong;YE Hong(Gynecological Minimal Invasive Centre, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100006, China)
出处
《现代药物与临床》
CAS
2018年第6期1424-1427,共4页
Drugs & Clinic
