摘要
目的探讨血清降钙素原,C-反应蛋白及肿瘤坏死因子-α在评估急性胰腺炎中的临床意义。方法收集轻症急性胰腺炎30例,重症胰腺炎42例及健康对照组30例为研究对象,动态监测其入院第1、4和7天血清PCT,CRP及TNF-α水平。结果急性胰腺炎相关指标PCT、CRP及TNF-α在各个时间段均高于对照组,差异有统计学意义(P<0.05);PCT、TNF-α均在急性胰腺炎组中第4天出现峰值,且两组均在第7天PCT及TNF-α指标呈下降趋势,但SAP组下降不明显,两组差异有统计学意义(P<0.05);CRP水平在第1天达峰值,在第4天MAP组降至正常高值,而SAP组甚至到第7天仍维持较高水平,两组差异有统计学意义(P<0.05)。结论血清PCT、CRP及TNF-α等指标联合的监测对于急性胰腺炎的诊断,判断预后及指导治疗具有很好的指导意义。
Objective To investigate the clinical significance of serum procalcitonin（PCT）,C-reactive protein（CRP） and tumor necrosis factor alpha（TNF-alpha） in the assessment of acute pancreatitis. Methods Thirty cases of mild acute pancreatitis（MAP）,42 cases of severe pancreatitis（SAP） and 30 cases of healthy controls were collected as the object of study.Serum PCT,CRP and TNF-alpha levels of all patients were monitored dynamically at 1,4 and 7 days after admission. Results Acute pancreatitis related indicators PCT,CRP and TNF-alpha in all time periods were higher than those in the control group（P〈0.05）.PCT,TNFalpha were all peak in fourth days of acute pancreatitis,and the index of PCT and TNF-alpha in the two groups declined in seventh days,but the decrease in the SAP group was not obvious,and the difference between the two groups was statistically significant（P〈0.05）.The CRP level reached the peak at first days,and the MAP group decreased to the normal high value in the fourth day group,while the SAP group even maintained a high level in the seventh day,and the difference between the two groups was statistically significant（P〈0.05）. Conclusion The combined monitoring of serum PCT,CRP and TNF-alpha is of great guiding significance for the diagnosis,prognosis and guiding treatment of acute pancreatitis.
作者
王坤玉
叶春芬
WANG Kunyu;YE Chunfen(The affiliated Tianyou Hospital of Wuhan University of Science and Technology,Wuhan 430064,Chin)
出处
《中国医药科学》
2018年第9期174-176,190,共4页
China Medicine And Pharmacy
