摘要
目的分析部激素依赖性皮炎应用氟芬那酸丁酯以及rh EGF治疗的效临床果。方法选取我院皮肤科收治的120例面部激素依赖性皮炎的患者,随机将其分为观察组和对照组各60例,观察组采用氟芬那酸丁酯软膏联合rh EGF凝胶治疗,对照组采用氟芬那酸丁酯单独治疗。观察临床效果,统计复发率及不良反应率。结果两组治疗4周后症状、体征积分显著较治疗前低(P<0.05),观察组的痊愈率为50.00%,总有效率93.33%,显著高于对照组的30.00%和78.33%(P<0.05)。治疗结束后8周时,复发率观察组为(10.00%),对照组为35.00%,差异有统计学意义(P<0.05)。两组患者不良反应的发生率差异无统计学意义(P>0.05)。结论面部激素依赖性皮炎联合氟芬那酸丁酯与重组人生长因子凝胶治疗疗效较好,且复发率较低,安全性高,值得在临床上进一步推广应用。
Objective To analyze the effect of flurfenac butyrate and rh EGF on hormone dependent dermatitis. Methods One hundred and twenty patients with facial hormone dependent dermatitis were randomly divided into two groups： observation group（n=60） and control group（n=60）.The patients were treated with flufenac butyrate ointment combined with rh EGF gel alone and flufenac butyrate alone.The clinical effect,recurrence rate and adverse reaction rate were observed. Results After 4 weeks of treatment,the scores of symptoms and signs in the two groups were significantly lower than those before treatment（P〈0.05）.The cure rate of the observation group was 50% and the total effective rate was 93.33%,which was significantly higher than that of the control group（30.00% and 78.33%,P〈0.05）.At 8 weeks after treatment, the recurrence rate was 10.0% in the observation group and 35.0% in the control group（P〈0.05）. There was no significant difference in the incidence of adverse reactions between the two groups（P〉0.05）. Conclusion Facial hormone dependent dermatitis combined with flurfenac butyrate and recombinant human growth factor gel has a good curative effect,low recurrence rate and high safety,so it is worthy of further application in clinic.
作者
陈国生
李耀辉
林玉辉
CHEN Guosheng;LI Yaohui;LIN Yuhui(Department of Dermatology and Venereal Diseases,Anbu Overseas Chinese Hospital,Chao＇an District,Chaozhou 515638,China)
出处
《中国医药科学》
2018年第10期57-59,共3页
China Medicine And Pharmacy
