摘要
建立了气相色谱-串联质谱法测定气雾剂中的17种多环芳烃浸出物,并对市售吸入气雾剂中的多环芳烃浸出物进行检测。样品经DB-5MS毛细管色谱柱分离,以多反应监测(MRM)模式检测。17种多环芳烃均有较好的线性关系,相关系数(R2)≥0.993 4;检测限均不大于2.0 ng/ml;平均回收率为84.3%~105.8%。11批市售气雾剂中的多环芳烃浸出量为每罐70.41~245.96 ng。本研究建立的检测方法灵敏度高、专属性好、结果准确,可作为气雾剂中多环芳烃浸物检测的通用方法。
A GC-MS/MS method was established for the determination of 17 polycyclic aromatic hydrocarbons （PAHs） as leachables in meter dose inhalers （MDI）. The leached PAHs in commercial MDIs were inspected by the validated method, which was based on GC-MS/MS in multiple reaction monitoring （MRM） mode. Calibration curves of 17 PAHs were all linear with correlation coefficients R2 no less than 0.993 4, and their limits of detection were no more than 2.0 ng/ml. Their recoveries were 84.3 %-105.8%. PAHs were all detected in all valve systems with the same formulation. With the extension of storage time, the PAHs cumulative leaching amount increased. PAHs leaching amount of 11 batches of commercially MDIs were 70.41-245.96 ng per canister. The established method was sensitive, specific, accurate, and suitable for the detection of PAHs in aerosols.
作者
叶晓霞
马娟
金方
杨永健
YE Xiaoxia;MA Juan;JIN Fang;YANG Yongjian(Shanghai Institute for Food and Drug Control, Shanghai 201203;Fudan University, Shanghai 201203;Shanghai Front Health Pharmaceutical Technology Co., Ltd., Shanghai 201203)
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2018年第7期994-998,共5页
Chinese Journal of Pharmaceuticals
关键词
气雾剂
多环芳烃
浸出物
气质联用
meter dose inhaler
polycyclic aromatic hydrocarbon
leachable
GC-MS/MS
