摘要
目的评估常用的实验室指标在预测过敏性紫癜(HSP)患儿发生并发症的价值。方法回顾性分析贵州省人医院儿科2016年3月1日至2017年3月31日期间HSP患儿的临床资料和入院首次血液学指标。纳入研究对象分为四组:(1)单纯HSP组;(2)HSP合并胃肠道症状组;(3)HSP合并肾脏损害患组;(4)HSP合并胃肠道症状和肾脏损害组。使用受试者工作特征曲线(ROC)确定HSP患儿出现并发症的最佳指标和切点值。结果共有纳入136例患儿,男84例(61.8%),平均年龄(8.0±2.9)岁。常用的血液学指标中:白细胞、血小板、中性粒细胞绝对值、中性粒细胞与淋巴细胞比值(NLR)、CRP在各组间差异具有统计学意义(P<0.05),合并有胃肠道症状组患儿的相关指标值要明显高于其他3组。在具有统计学差异的指标中,CPR曲线下面积最大为70.1%(95%CI:0.586~0.815)CRP取值6.5时,其灵敏度为71.1%,特异度为61%。结论 CRP可作为预测HSP患儿胃肠道并发症的有用指标,早期评估CRP水平对于判断HSP患儿预后具有一定的临床意义。
Objective To evaluate the value of common laboratory tests for predicting the complications inchildren with Henoch-Schonlein purpura（HSP）. Methods The clinical data and laboratory tests of children withHSP from 1 March 2016 to 31 March 2017 at Guizhou Provincial People′s Hospital was retrospectively analyzed.Patients were classified into four groups as follow：（1）simple HSP;（2）HSP with gastrointestinal symptoms;（3）HSP with nephritis;（4）HSP with gastrointestinal symptoms and nephritis. The laboratory marker and optimal cut-off value were determined by using a receiver operating characteristics curve（ROC）,area under the curve（AUC）and the Youden index. Results Total of 136 HSP cases were eligible for inclusion in this study,including 84 boys（61.8%）,mean age（8.0 ± 2.9）years. The difference of white blood cells,platelets,neutrophils,neutrophilsand lymphocytes ratio（NLR）,and CRP was statistically significant among the groups（P〈0.05）,the level ofthese laboratory test in children with gastrointestinal symptoms group was significantly higher than that in othergroups. We choose CRP,platelets,and NLR to draw ROC curve,the CRP achieved optimal AUC 70.1%（95%CI：0.586 - 0.815）,and the cut-off value of CRP was 6.5 with the sensibility at 71.1% and the specificity at61.0%. Conclusion The CRP is a useful indicator for predicting gastrointestinal complications,the early test ofCPR level is particularly helpful for determining prognosis of children with HSP.
作者
曾泽英
刘烨
陈智荷
范丽
崔玉霞
周浩
ZENG Zeying;LIU Ye;CHEN Zhihe;FAN Li;CUI Yuxia;ZHOU Hao(Physical Examination Center,Guizhou Provincial People′s Hospital,Guiyang 550002,Chin)
出处
《实用医学杂志》
CAS
北大核心
2018年第11期1847-1850,共4页
The Journal of Practical Medicine
基金
贵州省科技合作项目(编号:黔科合LH2015-7144号)
关键词
过敏性紫癜
并发症
实验室指标
儿童
henochoschonlein purpura（HSP）
adverse events
laboratory tests
children
