摘要
目的探讨左室Tei指数早期评价高血压肿瘤患者接受联合放、化疗后心脏功能改变的临床价值。方法将高血压肿瘤患者按左室质量指数分为高血压左室肥厚组30例与高血压无左室肥厚组30例,选取血压正常肿瘤患者30例作为对照组,通过多普勒超声心动图依次检测观察组与对照组患者放、化疗前后左室Tei指数以及各项心功能指标,比较3组各项心功能基础测量值和左室Tei指数变化的差异。结果高血压左室肥厚组放、化疗后的左室Tei指数高于对照组和高血压无左室肥厚组,差异有统计学意义(P<0.05),而对照组和高血压无左室肥厚组放、化疗后的左室Tei指数差异无统计学意义(P>0.05)。3组化疗后左心室射血分数、二尖瓣口舒张早期与舒张晚期血流峰值之比、收缩末期容积改变均无统计学意义。结论与传统超声指标比较,Tei指数可更敏感地反映高血压左室肥厚患者放、化疗前后的心脏功能改变,具有很好的临床应用价值。
Objective To assess the clinical value of left ventricular Tei-index in early evaluation of cardiac function in hypertensive patients with left ventricular hypertrophy after radiochemotherapy. Methods Thirty hypertensive patients with malignancies and left ventricular hypertrophy and 30 hypertensive patients with malignancies without left ventricular hypertrophy were enrolled in this study, with 30 normotensive patients with malignancies as the control group. Left ventricular Tei-index and cardiac function indexes of the patients were detected using Doppler echocardiography before and after radiochemotherapy, and the changes in the cardiac function index and left ventricular Tei-index were compared among the 3 groups. Results After radiochemotherapy, left ventricular Tei-index was significantly higher in hypertensive patients with left ventricular hypertrophy than in the control patients and hypertensive patients without left ventricular hypertrophy（P〈0.05）, and was similar between the latter two groups. No significant differences were found in the changes of left ventricular ejection fraction（EF）, ratio of the early to late ventricular filling velocities（E/A ratio）, or end-systolic volume（EDV）among the 3 groups after radiochemotherapy. Conclusion Tei-index is more sensitive than traditional echocardiography in assessing the changes of cardiac functions in hypertensive patients with left ventricular hypertrophy after chemotherapy.
作者
黄邹琴
李涛
HUANG Zouqin;LI Tao(Affiliated Cancer Hospital of Guangzhou Medical University, Guangzhou 510095, China)
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2018年第6期761-764,共4页
Journal of Southern Medical University
基金
广东省自筹经费类科技计划(粤科规财字【2015】110号)
广州市医学重点学科建设项目
关键词
TEI指数
高血压
左室肥厚
心脏功能
ndex
hypertension
left ventricular hypertrophy
cardiac function
