摘要
目的研究肥胖高血压患者在不同胰岛素抵抗状况下血脂及超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)的变化。方法选择2015年6月至2016年12月西宁市第一人民医院一分院收治的高血压住院患者115例,其中符合肥胖标准者65例。取65例肥胖高血压患者胰岛素敏感性指数中位数为界,将肥胖高血压患者分为胰岛素抵抗组(38例)与非胰岛素抵抗组(27例),比较两组血脂、hs-CRP水平及肥胖相关指标的差异。结果 (1)胰岛素抵抗组与非胰岛素抵抗组比较,腹围和腰臀比均升高[(96.14±5.84)cm vs(92.42±5.54)cm,P<0.05;(0.94±0.06)vs(0.91±0.07),P<0.01],hs-CRP水平明显升高[(2.27±0.86)mg/l vs(1.40±0.75)mg/l,P<0.05]。两组间胆固醇、甘油三酯、高密度脂蛋白及低密度脂蛋白比较差异无显著性(P>0.05)。(2)肥胖高血压患者hs-CRP与胰岛素敏感性指数呈显著负相关(r=-0.31,P<0.01),与腹围、腰臀比、体重指数、胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白无明显相关性(P>0.05)。结论肥胖高血压伴胰岛素抵抗者,反映血管内皮炎症状态的敏感指标hs-CRP显著升高,其心血管发病风险可能增大。
Objective To observe the changes of lipids and hypersensitive C-reactive protein（hs-CRP） in different state of insulin resistance in obese hypertensive patients. Method 115 hospitalized hypertensive patients from 6-2015 to 12-2016 were enrolled, and 65 of them were obesity. According to the middle point of ISI of the total（ISI=0.14）, the obese hypertensive patients were divided into insulin resistance group（IR group, ISI0.14） and non-insulin resistance group（NIR group, ISI≥0.14）. Then we compared hs-CRP, TG, HDL, CHOL, LDL between the IR group and NIR group by SPSS 16.0. Result In the obese hypertensive patients, hs-CRP, WC and WHR are higher in the IR group than the NIR group[WC：（96.14±5.84）cm vs（92.42±5.54）cm, P〈0.05; WHR：（0.94±0.06） vs（0.91±0.07）, P〈0.01; CRP：（2.27±0.86）mg/L vs（1.40±0.75）mg/L, P〈0.05）]. Hs-CRP is only related to ISI in the obese hypertensive patients（R=-0.31, P〈0.01）. Conclusion Hs-CRP is higher in the obese hypertensive patients with insulin resistance,which reflects the greater risk of cardiovascular disease.
作者
范玉萍
雷延明
牟建军
FAN Yu-ping;LEI Yan-ming;MOU Jian-jun(The First Branch of Xining First People＇s Hospital Qinghai Datong 810100, China;, The First Affiliated Hospital of Xi ＇an Jiaotong University, Shanxi Xi ＇an 710061, China)
出处
《中国医刊》
CAS
2018年第6期613-615,共3页
Chinese Journal of Medicine
基金
"十三五"国家重点研发项目(2017YFC1307604)
关键词
肥胖
高血压
胰岛素抵抗
超敏C反应蛋白
Obesity
Hypertension
Insulin resistance
Hypersensitive C-reactive
