摘要
目前,卒中是全世界范围内死亡和致残的主要原因之一。最新的研究发现细胞外囊泡(extracellular vesicle,EV),通过水平转移母体细胞的蛋白质和核酸,参与细胞间通讯并调节受体细胞的生物学功能。EV介导的细胞间通讯与卒中的发生、发展密切相关,并逐步成为卒中防治研究的热点。本文就EV内含物的分子组成与生物学功能在缺血性卒中发生、发展中的作用做简要综述。
Nowadays,stroke is one of the leading causes of death and disability worldwide.Recent studies suggest that extracellular vesicles（EV） play an important role in intercellular communication by transferring their components including protein,RNA and DNA between source and target cells in the brain.The transferred components in EVs can regulate the biological functions of the recipient cells,and participate in the pathogenesis of stroke,which gradually become the study hotspot in stroke prevention and treatment.This paper is to review these advances and their impact of EV molecular composition and biological function on ischemic stroke.
作者
蔡晋
资文杰
刘新峰
CAI Jin;ZI Wen-Jie;LIU Xin-Feng(Department of Geriatrics, the 455th Hospital of PLA, Shanghai 200052, China;Department of Neurology, the Nanjing General Hospital of PLA, Nanjing 210002, China)
出处
《中国卒中杂志》
2018年第4期372-376,共5页
Chinese Journal of Stroke
基金
国家自然科学基金青年科学基金项目(81400332)
关键词
卒中
细胞外囊泡
细胞间通讯
Stroke
Extracellular vesicle
Intercellular communication
