摘要
凝胶贴膏属于新型透皮给药载体,可以克服传统橡皮膏、黑膏药使用不便、刺激性强等缺点,是中药现代化的重要一环,但目前其发展被基质辅料种类、挥发性药物处理方式等关键因素制约。对2000—2017年与中药凝胶贴膏基质优化和挥发油处理方式有关的文献共254篇进行整理,以凝胶贴膏基质种类及辅料配比范围、优化基质配比的实验设计方法、凝胶贴膏中挥发油处理方式3个方面进行综述,并对其中存在的问题进行讨论,以期为后续研究提供借鉴。
Cataplasma is a new transdermal drug delivery carrier, playing a significant role in the modernization of Chinese materia medica（CMM）. It can overcome many shortcomings such as inconvenient use and intense irritation in traditional adhesive plaster and black plaster. However, the development of cataplasma is restricted by some crucial factors like the types of auxiliary materials and the processing ways of volatile medicine. A total of 254 articles related to CMM cataplasma optimization and the volatile oil treatment published from 2000 to 2017 were collected and sorted in this paper. The matrix types and excipients ratio scope, the experiment design method of optimized ratio of base material, and the processing ways of volatile oil in cataplasma were summarized, and then the existing problems in these three aspects mentioned above were discussed with view to giving reference for follow-up studies.
作者
王奕博
杜梓萱
黄特辉
杜媛媛
蔡梦如
曲昌海
尹兴斌
倪健
WANG Yi-bo;DU Zi-xuan;HUANG Te-hui;DU Yuan-yuan;CAI Meng-ru;QU Chang-hai;YING Xing-bin;NI Jian(School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China)
出处
《中草药》
CAS
CSCD
北大核心
2018年第11期2715-2721,共7页
Chinese Traditional and Herbal Drugs
基金
北京市科学技术委员会"十病十药"研发项目(Z171100001717014)
关键词
凝胶贴膏剂
基质配比
实验设计方法
挥发油
辅料
cataplasma
matrix formulation
experiment design method
volatile oil
excipients
