摘要
目的:探讨自拟痛风方联合中药离子导入治疗痛风高尿酸血症的临床疗效。方法:选取痛风高尿酸血症患者102例,依据随机数字表法分为治疗组与对照组各51例。对照组采取常规治疗,治疗组在对照组基础上采用自拟痛风方联合中药离子导入治疗,均持续治疗1个月。对比两组总有效率、不良反应发生率及治疗后3个月复发率,并比较两组治疗前、治疗1个月后血清肾功能指标[尿素氮(BUN)、血肌酐(Scr)]、炎性因子指标[白细胞介素1β(IL-1β)、白细胞介素6(IL-6)、C-反应蛋白(CRP)]、血尿酸(UA)、血沉(ESR)水平。结果:治疗组总有效率(94.12%)高于对照组(76.47%),差异有统计学意义(P<0.05);治疗1个月后两组比较,治疗组血清BUN、Scr、UA、ESR水平均低于对照组,差异均有统计学意义(P<0.05);治疗组血清IL-1β、IL-6、CRP水平均低于对照组,差异均有统计学意义(P<0.05);治疗组不良反应发生率(21.57%)与对照组(15.69%)比较,差异无统计学意义(P>0.05);治疗后3个月治疗组复发率(5.88%)低于对照组(25.49%),差异有统计学意义(P<0.05)。结论:自拟痛风方联合中药离子导入治疗痛风高尿酸血症患者疗效显著,可明显促进尿酸排泄,改善患者肾功能,减轻炎症反应,减少疾病复发。
Objective： To study the clinical effect of self-made gout combination with traditional Chinese medicine iontophoresis in the treatment of gout hyperuricemia. Methods： A total of 102 patients with gout hyperuricemia were selected and randomly divided into treatment group and control group, 51 cases in each group.The control group was treated with conventional non-drug therapy and western medicine, while the treatment group was treated with self-made gout method combined with traditional Chinese medicine iontophoresis. Both groups were treated for 1 month. The total effective rate, the incidence of adverse reactions and treatment recurrence rate after 3 months were compared between two groups. The serum renal function index [Urea nitrogen（BUN）, serum creatinine（Scr）], inflammatory factors [Interleukin-1β（IL-1β）, Interleukin-6（IL-6）, C-reactive protein（CRP）], Blood uric acid（UA）, and erythrocyte sedimentation rate（ESR） levels before and after 1 month of treatment were compared at the same time. Results： The total effective rate in the treatment group（94.12%） was significantly higher than the control group（76.47%）, the difference was statistically significant（P〈0.05）. The serum BUN, Scr, UA and ESR levels in the treatment group were significantly lower than the control group after 1 month treatment, the difference was statistically significant（P〈0.05）. The serum IL-1β, IL-6, CRP levels of treatment group were significantly lower than the control group the difference was statistically significant（P〈0.05）. There was no significant difference in the adverse reaction rate between the treatment group（21.57%） andthe control group（15.68%（8/51））（P〉0.05）. The recurrence rate in the treatment group（5.88%） was lower than that in the control group（25.49%） after 3 months treatment, the difference was statistically significant（P〈0.05）.Conclusion： The effect of gout combined with traditional Chinese medicine iontophoresis on patients with gouty hyperuricemia is effective. It can obviously promote uric acid excretion, improve the renal function, alleviate the inflammatory reaction and reduce the recurrence of the disease.
作者
张永健
朱立春
梅冬艳
薛秀娟
ZHANG Yong-jian;ZHU Li-chun;MEI Dong-yan;XUE Xiu-juan(Qinhuangdao TCM Hospital, Qinhuangdao Hebei 066000, Chin)
出处
《中医药导报》
2018年第13期80-83,共4页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
秦皇岛市科技支撑计划项目(201502A138)
