摘要
目的：探讨逍遥丸联合盐酸多奈哌齐治疗血管性痴呆伴发抑郁临床疗效。方法：选自医院于2015年1月—2016年12月期间收治的血管性痴呆伴发抑郁患者90例,按照随机数字表法分为观察组45例与对照组45例。观察组采用逍遥丸联合盐酸多奈哌齐治疗,对照组仅采用盐酸多奈哌齐治疗。两组疗程均为8周。比较两组治疗疗效,治疗前后简易智能状态检查量表（MMSE）评分、日常生活活动能力（ADL）评分及汉密尔顿抑郁量表（HAMD）评分,治疗前后血清多巴胺（DA）、脑源性神经营养因子（BDNF）、同型半胱氨酸（Hcy）变化,及不良反应发生情况。结果：观察组治疗总有效率（91.11%）高于对照组（71.11%）（P〈0.05）;两组治疗后MMSE、ADL评分增加而HAMD评分降低（观察组：t=16.485 9、19.464 0、33.542 3,对照组t=9.937 9、9.511 3、18.058 7,P〈0.05）;观察组治疗后MMSE、ADL评分高于对照组而HAMD评分低于对照组（t=6.141 4、8.804 6、16.327 3,P〈0.05）;两组治疗后血清DA、BDNF水平增加而Hcy水平降低（观察组：t=15.111 4、16.716 7、20.860 2,对照组t=7.361 2、8.359 1、9.510 5,P〈0.05）;观察组治疗后血清DA、BDNF水平高于对照组而Hcy水平低于对照组（t=6.739 4、7.818 1、14.181 0,P〈0.05）;观察组不良反应发生率（8.89%）低于对照组（28.89%）（P〈0.05）。结论：逍遥丸联合盐酸多奈哌齐治疗血管性痴呆伴发抑郁临床疗效显著,具有重要研究意义。
Objective： To investigate the clinical efficacy of Xiaoyao Pills combined with donepezil hydrochloride in the treatment of vascular dementia combined with depression. Methods： Ninety cases of vascular dementia combined with depression were selected from our hospital from January 2015 to December 2016. According to the random number table,the patients were divided into the observation group（ 45 cases） and the control group（ 45 cases）. The observation group was treated with Xiaoyao Pills and donepezil hydrochloride,while the control group was treated with donepezil hydrochloride. The two groups were treated for 8 weeks. The treatment effect was compared between the two groups before and after treatment,Mini Mental State Examination（ MMSE） score,activities of daily life ability score（ ADL） and Hamilton Depression Scale（ HAMD） score before and after treatment,serum levels of dopamine（ DA）,brain-derived neurotrophic factor（ BDNF） and homocysteine（ Hcy） changes and adverse reactions were compared. Results： The total effective rate of the observation group（ 91. 11%） was higher than that of the control group（ 71. 11%）（ P〈 0. 05）. The scores of MMSE and ADL increased and HAMD scores decreased in the two groups after treatment（ observation group： t = 16. 485 9,19. 464 0,33. 542 3; control group： t = 9. 937 9,9. 511 3,18. 058 7,P〈 0. 05）. The scores of MMSE and ADL in the observation group were higher than those in the control group,but the HAMD score was lower than that in the control group（ t = 6. 141 4,8. 804 6,16. 327 3,P〈 0. 05）. Serum DA and BDNF levels increased and Hcy levels decreased in the two groups（ observation group： t = 15. 111 4,16. 716 7,20. 860 2; control group： t = 7. 3612,8. 3591,9. 5105,P 0. 05）. The serum levels of DA and BDNF in the observation group were higher than those in the control group,while the level of Hcy was lower than that in the control group（ t = 6. 739 4,7. 818 1,14. 181 0,P〈 0. 05）. The incidence of adverse reactions in observation group（ 8. 89%） was lower than that in control group（ 28. 89%）（ P〈 0. 05）. Conclusion：Xiaoyao Pills combined with donepezil in the treatment of vascular dementia combined with depression has a significant clinical effect,and has important research significance.
作者
沈莹
余鸽
张海生
SHEN Ying;YU Ge;ZHANG Haisheng(Department of Geriatrics, Tongde Hospital of Zhejiang Province, Hangzhou 310000,Zhejiang, China;Department of Clinical Psychology, No. 1 People＇ s Hospital of Hangzhou, Hangzhou 310013,Zhejiang, China)
出处
《中华中医药学刊》
CAS
北大核心
2018年第7期1724-1726,共3页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省中医药管理局科研基金项目(ZC31611)
关键词
逍遥丸
盐酸多奈哌齐
血管性痴呆
抑郁
Xiaoyao Pill
donepezil hydrochloride
vascular dementia
depression
