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血必净对于感染性休克患者血清TNF-α及凝血功能的影响 被引量:13

Study on Effect of Xuebijing Injection on Serum Tumor Necrosis Factor-α and Blood Coagulation in Patients with Septic Septic Collision with Septic Shock
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摘要 目的:观察血必净注射液对于脓毒败血症合并感染性休克患者血清肿瘤坏死因子-α及凝血功能的影响。方法:采用随机、单盲临床试验方法,选择200例脓毒败血症合并感染性休克(淤血证)患者,随机分为观察组和对照组,各100例,两组患者均给予包括抗生素、液体支持治疗、营养支持治疗等;观察组在此基础上给予血必净注射液100 m L静脉滴注,2次/d。14 d为1个疗程。治疗前和治疗第7天、第14天分别对患者进行血清肿瘤坏死因子-α(TNF-α)及凝血功能检测。然后对两组患者进行了长达12个月的随访。结果:与治疗前相比较,两组患者在治疗7 d后血清TNF-α均有所降低,凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)及纤维蛋白原(Fbg)含量均有所增加(均P〈0.05),但组间比较无明显差异(均P〉0.05);治疗14 d后,观察组的血清TNF-α水平明显低于对照组,凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)及纤维蛋白原(Fbg)含量明显高于对照组,两组差异有统计学意义(均P〈0.05);疗程结束观察组总有效率优于对照组(P〈0.05)。结论:血必净注射液能够有效地降低脓毒败血症合并感染性休克患者的血清TNF-α水平,增加PT、APTT以及Fbg水平,临床疗效好,安全性高,值得在临床上大力推广应用。 Objective: To observe the effect of Xuebijing Injection on serum tumor necrosis factor-α and coagulation function in septic sepsis patients with septic shock. Methods: A randomized,single-blind clinical trial was used to select 200 patients with sepsis and septic shock(syndrome). The patients were randomly divided into observation group and control group. Each group was given antibiotics and liquid supportingtreatment,nutritional supporting treatment,etc. The observation group on the basis of this would be given 100 m L intravenous infusion,once a day. 14 days was for a course of treatment. The levels of serum tumor necrosis factor-α(TNF-α) and coagulation test were measured before,7 and 14 days after treatment. Patients were then followed up for 12 months. Results: Compared with those before treatment,serum TNF-α was decreased in the two groups after 7 daystreatment and the levels of prothrombin time(PT),activated partial thrombin time(APTT) and fibrinogen(Fbg) increased(P〈0. 05). However,the levels of serum TNF-α in the observation group were significantly lower than those in the control group(P〈0. 05),but there was no significant difference between the two groups(P〈0. 05). APTT and Fbg were significantly higher than those in the control group(P〈0. 05). The total effective rate of the treatment group was better than that of the control group(P〈0. 05). Conclusion: Xuebijing Injection can effectively reduce the serum TNF-α level and increase the levels of PT,APTT and Fbg in patients with septic sepsis and septic shock. The clinical efficacy is good and the safety is high,which is worthy of popularization and application in clinical practice.
作者 李波 陈国兵 葛利 LI Bo;CHEN Guobing;GE Li(EICU ,The Frist People's Hospital of Yunnan Province, Kunming 650032, Yunnan, Chin)
出处 《辽宁中医杂志》 CAS 2018年第5期977-979,共3页 Liaoning Journal of Traditional Chinese Medicine
基金 国家自然科学基金,地区科学基金项目(81660316)
关键词 脓毒败血症 感染性休克 血必净注射液 sepsis septic shock Xuebijing Injection
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