摘要
目的探讨老年高尿酸血症（HUA）患者血浆内皮素-1和一氧化氮水平与听力受损的关系。方法回顾性分析2013年9月至2016年3月体检的174例老年人的临床资料，其中HUA 81例（HUA组），无HUA 93例（对照组）。两组患者行纯音听力和听觉脑干反应检测，并检测血浆内皮素-1、一氧化氮。结果HUA组250、500、1 000、2 000、4 000和8 000 Hz纯音听力均明显高于对照组[（33.03 ± 12.09）dB比（28.49 ± 9.89）dB、（35.56 ± 13.47）dB比（27.31 ± 9.34）dB、（38.81 ± 14.94）dB比（29.78 ± 9.39）dB、（43.62 ± 16.45）dB比（37.06 ± 12.66）dB、（51.07 ± 18.36）dB比（46.29 ± 15.15）dB和（65.75 ± 18.76）dB比（57.71 ± 20.26）dB]，差异有统计学意义（P〈0.01）。HUA组Ⅰ波、Ⅲ波、Ⅴ波潜伏期和Ⅰ~Ⅲ波、Ⅰ~Ⅴ波间期均明显长于对照组[（2.10 ± 0.26）ms比（2.03 ± 0.24）ms、（4.11 ± 0.38）ms比（3.89 ± 0.31）ms、（5.94 ± 0.31）ms比（5.69 ± 0.29）ms、（2.01 ± 0.26）ms比（1.86 ± 0.22）ms和（3.83 ± 0.28）ms比（3.65 ± 0.25）ms]，差异有统计学意义（P〈0.01）；两组Ⅲ~Ⅴ波间期比较差异无统计学意义（P〉0.05）。HUA组Ⅴ波阈值明显大于对照组[（45.61 ± 11.18）dB比（41.98 ± 9.37）dB]，差异有统计学意义（P〈0.05）。HUA组血浆内皮素-1水平明显高于对照组[（16.96 ± 3.45）ng/L比（11.64 ± 3.81）ng/L]，血浆一氧化氮水平明显低于对照组[（0.98 ± 0.66）μmol/L比（1.36 ± 1.08）μmol/L]，差异有统计学意义（P〈0.05或〈0.01）。结论血浆内皮素-1水平升高和一氧化氮水平降低是老年HUA患者听力受损的可能机制。
ObjectiveTo investigate the relationship between plasma endothelin-1 and nitric oxide levels and hearing impairment in elderly patients with hyperuricemia （HUA）.MethodsThe clinical data of 174 physical examination elderly from September 2013 to March 2016 were retrospectively analyzed. Among them, the HUA was in 81 cases （HUA group）, and no HUA was in 93 cases （control group）. The pure tone hearing and high stimulation rate of auditory brainstem response were tested, and the plasma endothelin and nitric oxide levels were detected.ResultsThe pure tone hearing of 250, 500, 1 000, 2 000, 4 000 and 8 000 Hz in HUA group were significantly higher than those in control group： （33.03 ± 12.09） dB vs. （28.49 ± 9.89） dB, （35.56 ± 13.47） dB vs. （27.31 ± 9.34） dB, （38.81 ± 14.94） dB vs. （29.78 ± 9.39） dB, （43.62 ± 16.45） dB vs. （37.06 ± 12.66） dB, （51.07 ± 18.36） dB vs. （46.29 ± 15.15） dB and （65.75 ± 18.76） dB vs. （57.71 ± 20.26） dB, and there were statistical differences （P〈0.01）. The Ⅰ wave, Ⅲ wave, Ⅴ wave latency and Ⅰ to Ⅲ wave, Ⅰ to Ⅴ wave intervals in HUA group were significantly longer than those in control group： （2.10 ± 0.26） ms vs.（2.03 ± 0.24） ms, （4.11 ± 0.38） ms vs. （3.89 ± 0.31） ms, （5.94 ± 0.31） ms vs. （5.69 ± 0.29） ms, （2.01 ± 0.26） ms vs. （1.86 ± 0.22） ms and （3.83 ± 0.28） ms vs. （3.65 ± 0.25） ms, and there were statistical differences （P〈0.01）. There was no statistical difference in Ⅲ to Ⅴ wave interval between 2 groups （P〉0.05）. The Ⅴ wave threshold value in HUA group was significantly higher than that in control group： （45.61 ± 11.18） dB vs. （41.98 ± 9.37） dB, and there was statistical difference （P〈0.05）. The plasma endothelin-1 level in HUA group was significantly higher than that in control group： （16.96 ± 3.45） ng/L vs. （11.64 ± 3.81） ng/L, the plasma nitric oxide level was significantly lower than that in control group： （0.98 ± 0.66） μmol/L vs. （1.36 ± 1.08） μmol/L, and there were statistical differences （P〈0.05 or〈0.01）.ConclusionsElevated plasma endothelin-1 level and reduced nitric oxide level may be a possible mechanism for hearing impairment in elderly patients with hyperuricemia.
作者
王建
范静平
Wang Jian;Fan Jingping(Department of General Practice, Yangpu District Wujiaochang Street Community Health Service Center, Shanghai 200434, Chin)
出处
《中国医师进修杂志》
2018年第7期609-612,共4页
Chinese Journal of Postgraduates of Medicine
基金
上海市杨浦区卫生和计划生育委员会重点项目（[2013]91号）
上海市杨浦区卫生和计划生育委员会青年科研项目（201303）
