摘要
目的:探讨环孢素A治疗糖皮质激素抵抗的重度溃疡性结肠炎的临床疗效。方法:选取郑州市第九人民医院(以下简称我院)2014年10月至2016年10月诊治的糖皮质激素抵抗的重度溃疡性结肠炎患者112例,采用随机数字表法分为两组,对照组患者实施常规治疗,观察组患者联用环孢素A治疗,比较两组患者的病症改善时间、治疗效果、不良反应情况。结果:两组患者治疗后C反应蛋白、白细胞介素-6、肿瘤坏死因子α、Southerland评分、VAS评分较治疗前降低(P<0.05)。两组患者治疗后日常活动能力评分较治疗前增加(P<0.05)。观察组患者治疗后C反应蛋白、白细胞介素-6、肿瘤坏死因子α、Southerland评分、VAS评分低于对照组(P<0.05)。观察组患者治疗后日常活动能力评分、总有效率高于对照组(P<0.05)。观察组患者腹泻消失时间、腹痛消失时间、溃疡消失时间早于对照组(P<0.05)。观察组患者住院时间少于对照组(P<0.05)。两组患者不良反应(肝肾功能指标异常、血压升高、过敏反应、恶心呕吐、头晕头痛、胃肠道反应)比较,差异无统计学意义(P>0.05)。结论:环孢素A治疗糖皮质激素抵抗的重度溃疡性结肠炎的临床疗效显著,可明显改善患者的临床病症,减轻炎性反应,加速术后恢复进程,值得临床推广使用。
Objective： This study was designed to investigate clinical effect of cyclosporin A in the treatment for severe glucocorticoid-resistant ulcerative colitis. Methods： 112 patients with severe glucocorticoid-resistant ulcerative colitis were selected in No.9 Zhengzhou People＇s Hospital from October 2014 to October 2016, who were divided into two groups by random number table method. Control group received routine treatment. Observation group received treatment combined with cyclosporin A. Disease improvement time, treatment effect, and adverse reactions were compared between two groups. Results： C reactive protein, interleukin-6, tumor necrosis factor α Southerland score, VAS score after treatment decreased in two groups compared with before treatment（P〈0.05）. Daily activity score after treatment increased in two groups compared with before treatment（P〈0.05）. C reactive protein, interleukin-6, tumor necrosis factor α, Southerland score, VAS score after treatment in observation group were lower than control group（P〈0.05）. Daily activity score, total effective rate after treatment in observation group were higher than control group（P〈0.05）. Diarrhea disappearance time, abdominal pain disappearance time, ulcer disappearance time in observation group were earlier than control group（P〈0.05）. Hospitalization time in observation group was less than control group（P〈0.05）. There were no significant difference in adverse reactions（abnormal liver and kidney function, elevated blood pressure, allergic reaction, nausea and vomiting, dizziness and headache, gastrointestinal reaction） between two groups（P〉0.05）. Conclusion： Cyclosporin A has significant effect in treatment for glucocorticoid-resistant severe ulcerative colitis, which can significantly improve clinical symptoms and reduce inflammation response, which can also accelerate postoperative recovery process and worth clinical use.
作者
张兵兵
戴卫
张晓兵
王莉莉
张鲲鹏
ZHANG Bing-bing;DAI Wei;ZHANG Xiao-bing;WANG Li-li;ZHANG Kun-peng(Department of Gastroenterology, No.9 Zhengzhou People＇s Hospital, Zhengzhou 450000, Chin)
出处
《临床药物治疗杂志》
2018年第5期43-46,共4页
Clinical Medication Journal
