摘要
目的探讨结直肠癌患者外周血中性粒细胞与淋巴细胞比值(NLR)和红细胞分布宽度(RDW)的变化及临床诊断价值。方法回顾性分析2016年1月~2018年1月肿瘤科住院结直肠癌确诊患者116例为实验组,选取同期健康志愿者80例为对照组进行对比分析,通过ROC曲线、独立样本t检验等数据分析方法,比较两组NLR,RDW水平差异,评估各个指标在结直肠癌患者中的诊断作用。结果结直肠癌组外周血NLR和RDW明显高于健康对照组(2.99±2.14vs 1.71±0.5),(14.89%±2.69%vs 13.29%±0.47%),差异均有统计学意义(t=5.24,5.27,均P<0.001)。绘制ROC曲线,NLR曲线下面积为0.733,确定最佳截点为2.09,敏感度为58.8%,特异度为86.1%,按此临界点将结直肠癌患者分为高NLR组(≥2.09,67例)和低NLR组(<2.09,49例)。RDW曲线下面积为0.672,最佳截点为14.1%,敏感度为54.3%,特异度为93.1%,根据RDW水平的不同将患者分为高RDW组(≥14.1%,62例)和低RDW组(<14.1%,54例)。高值组和低值组的患者年龄、性别、肿瘤部位之间差异均无统计学意义(均P>0.05)。结论结直肠癌患者NLR和RDW水平显著升高,可以作为结直肠癌患者的一个临床辅助诊断指标。
Objective To investigate the changes and clinical significance of ratio of peripheral blood neutrophil to lymphocyte ratio （NLR） and red blood cell distribution width （RDW） in the colorectal cancer. Methods Retrospectively analysed of 116 cases of patients with colorectal cancer as objects group from January 2016 to January 2018. Meantime, 99 healthy volunteers were chosen as the control group. Through independent sample t test and ROC curve data analysis methods, the differences of PB-NLR and RDW levels of the two groups were compared and the diagnostic value in the various indicators in colorectal cancer were analyzed. Results The peripheral blood neutrophil NLR and RDW in the colorectal cancer groups were 2.99± 2.14 and 14.89% ±2.69% which were significantly higher than 1.71±0.5 and 13.29%±0.47% in the control group （t= 5.24,5.27,all P〈0. 001）. Depending on the level of NLR, ROC curve was analyzed to determine the best cutoff point was 2.09 in colorectal cancer patients, NLR area under the curve was 0. 733, the sensitivity and specificity were 58.6% and 86.1 % respectively. The area under the ROC curve was 0. 672, the optimum cutoff value of RDW was 14.1 %, the sensitivity and specificity were 54.3 % and 93.1% respectively. In addition, NLR and RDW were divided into high-value group and low- value group according to the optimal critical point. There was no statistically significant difference in age,gender, and tumor location between the high-value group and the low-value group of NLR and RDW （P〉0.05）. Conclusion The NLR and RDW are significantly elevated in patients with colorectal cancer,which could be used a clinical auxiliary diagnostic indicator for the assessment of patients with colorectal cancer.
作者
井丰军
倪勇
JING Feng-jun;NI Yong(Department of Clinical Laboratory, Wuhu Hospital of Traditional Chinese Medicine in Anhui Province ,Anhui Wuhu 241000,China)
出处
《现代检验医学杂志》
CAS
2018年第3期99-102,共4页
Journal of Modern Laboratory Medicine
关键词
结直肠癌
中性粒细胞与淋巴细胞比值
红细胞分布宽度
colorectal cancer
neutrophil to lymphocyte ratio （NLR）
red blood cell distribution width （RDW）
