摘要
卵巢癌具有起病隐匿、进展迅速、化疗易耐药等特点,多数患者预后不良。黏附分子CD44与肿瘤的发生、发展、侵袭、转移密切相关,但其在卵巢癌中的作用尚未完全阐明。本文就CD44与卵巢癌转移、化疗药物耐药、治疗及预后关系的研究进展作一综述。
Ovarian cancer has a poor prognosis because of its characteristics of concealment,rapid progress,and resistance to chemotherapy.The adhesion molecule CD44 is closely correlated with the occurrence and development,as well as invasion and metastasis of tumors,but its clinical significance in ovarian cancer has not yet been fully elucidated.This paper reviews the research progress of the relationship of CD44 with the metastasis,chemotherapy resistance,treatment and prognosis of ovarian cancer.
作者
何毅
杨慧
周云峰
HE Yi;YANG Hui;ZHOU Yun-feng(Department of Oncology , Zhongnan Hospital of Wuhan University, Wuhan 430071, China)
出处
《中华实用诊断与治疗杂志》
2018年第7期722-724,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
国家自然科学基金(81472799)
关键词
卵巢癌
黏附分子
CD44
Ovarian cancer
adhesion molecule
CD44