来氟米特联合糖皮质激素治疗系统性红斑狼疮的临床疗效及对血清IL-8和IL-10水平的影响被引量：4

Effect of Leflunomide and Corticosteroid in the Treatment of Systemic Lupus Erythematosus and its Effect on Serum IL-8 and IL-10 Levels

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摘要目的:探究对系统性红斑狼疮患者使用来氟米特联合糖皮质激素治疗的效果及对血清IL-8和IL-10水平产生的影响。方法:将2016年1月至2017年1月我院收治的82例系统性红斑狼疮患者随机分成两组进行研究,对照组行泼尼松联合羟氯喹治疗,研究组行泼尼松联合来氟米特治疗,对两组效果进行分析和比较。采用酶联免疫吸附试验(ELISA)对两组治疗前后血清IL-8和IL-10水平进行检测和比较。结果:研究组临床疗效优于对照组(P<0.05),且治疗后研究组血清IL-10水平明显低于对照组,血清IL-8水平明显高于对照组高,两组间比较差异明显(P<0.05)。结论:来氟米特免疫抑制作用较强,对轻症系统性红斑狼疮患者行来氟米特联合糖皮质激素治疗疗效确切,值得临床进一步使用观察。 Objective： To investigate the effect of leflunomide combined with glucocorticoid therapy on the level of IL-8 and IL-10 in patients with systemic lupus erythematosus.Methods： A total of 82 patients with systemic lupus erythematosus were randomly divided into two groups from January 2016 to January 2017. The control group was treated with prednisone and hydroxychloroquine. The rats were treated with prednisone and leflunomide Treatment, the two groups of effects were analyzed and compared. Results： The clinical curative effect of the study group was better than that of the control group（P〈0.05）.Conclusion： The treatment of patients with systemic lupus erythematosus with leflunomide combined with glucocorticoid can achieve the exact effect, can be used as first-line treatment.

作者陈新鹏陈娟曾惠琼卢小平张会昌叶志中 Chen Xinpeng(Futian District, Shenzhen Rheumatology Hospital （Shenzhen 518000)

机构地区深圳市福田区风湿病专科医院

出处《黑龙江医药》 CAS 2018年第3期585-587,共3页 Heilongjiang Medicine journal

关键词来氟米特糖皮质激素系统性红斑狼疮血清IL-8水平血清IL-10水平 Leflunomide Glucocorticoid Systemic lupus erythematosus Serum IL-8 level Serum IL-10 level

分类号 R593.24 [医药卫生—内科学]

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