摘要
目的:观察急性脑梗死患者接受丁苯酞联合阿托伐他汀治疗后血清超氧化物岐化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、NO水平的变化。方法:选取急性脑梗死患者112例,按随机数字表法分为试验组和对照组,每组56例,对照组患者在常规治疗的基础上给予阿托伐他汀钙片治疗,试验组患者给予丁苯酞软胶囊和阿托伐他汀钙片治疗。比较2组疗效及用药后不良反应发生情况,并分别于用药治疗前和治疗14 d后采集肘静脉血,检测血液动力学指标和血清SOD、GSH-Px、NO水平。结果:试验组有效率为92.86%(52/56),对照组为78.57%(44/56),组间差异具有统计学意义(P<0.05);治疗14 d后2组患者血浆黏度、全血高切黏度、全血低切黏度、红细胞压积、红细胞变形指数等血液动力学指标均明显改善,且试验组改善程度较对照组患者更为明显(P<0.05);治疗14 d后2组患者血清SOD、GSH-Px水平均明显升高,NO水平明显降低,且试验组上述指标的升高或降低程度较对照组患者更为明显(P<0.05);2组患者均未出现药物相关不良反应。结论:丁苯酞联合阿托伐他汀治疗急性脑梗死患者的临床疗效显著,可有效改善患者血液动力学指标和氧化应激水平。
Objective： To observe the effect of butylphthalide combined with atorvastatin treatment on serum levels of superoxide dismutase（ SOD）,glutathione peroxidase（ GSH-Px） and nitric oxide（ NO） in patients with acute cerebral infarction. Methods： 112 patients with acute cerebral infarction admitted on the Department of Neurology of our hospital from April2014 to August 2016 were selected and divided into experimental group and control group,each of 56 cases. Patients in control group received atorvastatin calcium tablets on the basis of conventional therapy,and those in experimental group received butylphthalide soft capsules combined with atorvastatin calcium tablets treatment. The efficacy was compared between the two groups,and the hemodynamics and serum levels of SOD,GSH-Px and NO before and after treatment were detected and compared between the two groups. The incidence of side effects was recorded in detail after the administration of the two groups.Results： The effective rate in the treatment group and control group was 92. 86%（ 52/56） and 78. 57%（ 44/56） respectively,with statistically significant difference（ P〈0. 05）. As compared with those before treatment,the hemodynamics indexes such as plasma viscosity,whole blood high shear viscosity,whole blood low shear viscosity,hematocrit and erythrocyte deformation index in both groups were significantly improved,more significantly in experimental group than in control group（ P〈0. 05）. As compared with those before treatment,the serum levels of SOD and GSH-Px in both groups were significantly increased,the serum levels of NO in both groups were significantly decreased,and those in experimental group increased or decreased more significantly than in control group,with statistically significant difference（ P〈0. 05）. There was no drugrelated adverse reaction after drug treatment in both groups. Conclusion： Butylphthalide combined with atorvastatin treatment for patients with acute cerebral infarction has significant clinical efficacy,and can effectively improve the patient＇s hemodynamics indexes and oxidative stress.
作者
姜永宁
JIANG Yong-ning(Dandong City Center Hospital of Liaoning Province,Dandong 1108002,China)
出处
《内科急危重症杂志》
2018年第3期206-209,共4页
Journal of Critical Care In Internal Medicine
