摘要
目的调查青海省不同地区甲状腺结节患者碘营养状况和促甲状腺激素水平，分析不同地区的变化特点。方法2014—2016年，在青海省对9个地区（藏区：歇武、囊谦、结古、果洛；非藏区：西宁、互助、门源、民和、乐都）的甲状腺结节患者进行尿碘及血清促甲状腺激素（TSH）测定。结果共调查甲状腺结节患者553例，尿碘中位数（MUIC）为160．8μg／L，TSH中位数为2．97mU／L，碘营养状况处于适宜水平。其中，门源地区甲状腺结节患者MUIC（206．8μg／L）略高于适宜量，各地区间MUIC比较差异有统计学意义（x2=47．747，P〈0．05）；9个地区甲状腺患者的TSH水平比较差异有统计学意义（x2=34．832，P〈0．05）。藏区与非藏区的甲状腺结节患者MUIC（155．6、185．6μg／L）、TSH（2．68、3．45mU／L）比较差异有统计学意义（Z=-3．677、5A10，P均〈0．05）；其中，女性甲状腺结节患者MUIC（152．8、187．7μg／L）比较差异有统计学意义（Z=-3．504，P〈0．05）；男（2．58、3．46mU／L）、女性甲状腺结节患者TSH水平（2．80、3．44mU／L）比较差异均有统计学意义（Z=-3．613、-4．040，P〈0．05）；各年龄组甲状腺结节患者尿碘水平比较差异无统计学意义（P均〉0．05）；30～（2．63、3．17mU／L）和55～〈65岁（2．25、3．58mU／L）年龄组偈H水平比较差异有统计学意义（Z=-2．892、-3．233，P均〈0．05），其余年龄组比较差异无统计学意义（P均〉0．05）。结论青海省上述地区甲状腺结节患者的碘营养整体处于适宜水平，但藏区MUIC和偈H水平均低于非藏区，应针对重点人群加强碘营养状况及髓H水平监测。
Objective To investigate the iodine nutritional and thyroid stimulating hormone level of patients with thyroid nodules in different regions of Qinghai Province and analyze the characteristics of changes in different regions. Methods In 2014 - 2016, thyroid nodules in 9 regions of Qinghai Province （Tibetan areas： Xiewu, Nangqian, Jiegu, Guoluo; non-Tibetan areas： Xining, Huzhu, Menyuan, Minhe, and LedU） were selected and serum thyroid stimulating hormone （TSH） and urine iodine were measured. Results A total of 553 thyroid nodules, the median urinary iodine （MUIC） was 160.8 μg/L and the median TSH was 2.97 mU/L. The iodine nutritional status was at an appropriate level. Among them, MUIC （206.8 μg/L） in thyroid nodules in the Menyuan area was slightly higher than the appropriate amount, there was a significant difference in MUIC among different region （X2 = 47.747, P 〈 0.05）; of TSH in thyroid nudules in the 9 regions, the differences were statistically significant （x2 = 34.832, P 〈 0.05）. Non-Tibetan areas were compared with Tibetan areas, there was a significant difference in MUIC （155.6, 185.6 μg/L）, TSH （2.68, 3.45 mU/L, Z = - 3.677, - 5.410, P 〈 0.05）; Among them, the differences was statistically significant between MUIC （152.8, 187.7 μg/L） of women with thyroid nodules （Z=- 3.504, P 〈 0.05）; there was a statistically significant difference in TSH levels among men （2.58, 3.46 mU/L） and women （2.80, 3.44 mU/L） with thyroid nodules （Z = - 3.613, - 4.040, P 〈 0.05）; there were no significant differences in MUIC levels among thyroid nodules of each age groups （P 〉 0.05）; of the TSH level in 30- and 50- 〈 65 years groups （2.63, 3.17; 2.25, 3.58 mU/L）, the differences were statistically significant （Z = - 2.892, - 3.233, P 〈 0.05）, and other groups were no significant differences （P 〉 0.05）. Conehlsion The iodine nutrition of patients with thyroid nodules in these regions of Qinghai Province is generally at an appropriate level, the MUIC and TSH levels in Tibetan areas were lower than those in non-Tibetan areas, and iodine nutrition status and TSH levels should be monitored for key populations.
作者
米娜
李正
崇显瑾
许海琦
李永桂
王叶
朱沁芳
李金娟
杨历新
李国彤
姜志晶
Mi No;Li Zheng;Chong Xianjin;Xu Haiqi;Li Yonggui;Wang Ye;Zhu Qinfang;Li Jinjuan;Yang Lixin;Li Guotong;Jiang Zhixiao(Department of Endocrinology, Qinghai Provincial People＇s Hospital, Xining 810000, China)
出处
《中华地方病学杂志》
CAS
CSCD
北大核心
2018年第7期565-567,共3页
Chinese Journal of Endemiology
基金
青海省基础科技计划项目（2014-SF-530）
关键词
甲状腺结节
尿
碘
促甲状腺激素
Thyroid nodule
Urine
Iodine
Thyroid stimulating hormone
