摘要
目的:探讨血清IgA、IgA/C3和IgA/C4比值水平在原发性IgA肾病与非IgA型肾病鉴别诊断中的价值。方法:收集经肾穿刺病理检测确诊的IgA型肾病64例和非IgA型肾病67例血清样本,用免疫比浊法检测病人血清IgA、C3与C4水平,并计算IgA/C3、IgA/C4的比值。通过绘制ROC曲线,并计算曲线下面积,比较血清IgA、IgA/C3和IgA/C4在预测IgA肾病的价值。结果:原发性IgA肾病病人血清IgA、IgA/C3和IgA/C4比值较其他肾小球性疾病组明显升高(P<0.01),IgA、IgA/C3和IgA/C4比值的ROC曲线下面积分别为0.692、0.718和0.747。结论:在无肾穿刺病理诊断的条件下,IgA和IgA/C3及IgA/C4比值在原发性IgA肾病鉴别诊断中可起一定辅助作用。
Objective： To investigate the value of the serum IgA,ratios of IgA/C3 and IgA/C4 in the differential diagnosis of primary IgA nephropathy and non-IgA nephropathy. Methods： The serum levels of IgA,C3 and C4 in 64 IgA nephropathy patients and 67 nonIgA nephropathy patients were detected using turbidimetric immunoassay,the ratios of IgA/C3 and IgA/C4 were calculated,the ROC curve were established,and the area under the curve was calculated. The significance of the serum IgA,ratios of IgA/C3 and IgA/C4 in predicting the IgA nephropathy was evaluated. Results： The serum IgA level,ratios of IgA/C3 and IgA/C4 in patients with primary IgA nephropathy significantly increased compared with other nephrotic patients（ P〈0. 01）,and the area under the ROC curve of the IgA,ratios of IgA/C3 and IgA/C4 was 0. 692,0. 718 and 0. 747,respectively. Conclusions： In the absence of pathological diagnosis of renal biopsy,the IgA,ratios of IgA/C3 and IgA/C4 can play an auxiliary role in the differential diagnosis of primary IgA nephropathy.
作者
李团团
LI Tuan-tuan(Clinical Laboratory,The Second People＇s Hospital of Fuyang,Fuyang Anhui 236015,China)
出处
《蚌埠医学院学报》
CAS
2018年第5期642-644,共3页
Journal of Bengbu Medical College
