摘要
目的:探讨四逆汤合四神丸加味治疗肝硬化脾肾阳虚型顽固性腹泻的临床疗效。方法:选取2014年1月至2018年1月江西省赣西监狱医院收治的肝硬化脾肾阳虚型顽固性腹泻患者120例,采用随机数字表法分为观察组和对照组,每组60例。对照组患者给予双八面体蒙脱石散治疗,观察组患者给予四逆汤合四神丸加味治疗。观察两组患者的临床疗效、肝功能指标[丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素(TBIL)和白蛋白(ALB)]及中医症状评分。结果:观察组患者的总有效率为95.00%(57/60),明显高于对照组的78.33%(47/60),差异有统计学意义(P<0.05);治疗后,观察组患者ALT、AST、ALB及TBIL水平明显优于对照组,差异均有统计学意义(P<0.05);治疗后,观察组患者平均中医症状评分为(2.36±1.12)分,明显低于对照组的(7.69±1.31)分,差异有统计学意义(P<0.05)。结论:四逆汤合四神丸加味治疗肝硬化脾肾阳虚型顽固性腹泻的疗效显著,可改善患者症状。
OBJECTIVE： To probe into the clinical efficacy of sini decoction combined with Sishen pills in treatment of liver cirrhosis with asdthenic splenonephro-yang of intractable diarrhea. METHODS： 120 patients with liver cirrhosis with asdthenic splenonephro-yang of intractable diarrhea admitted into Jiangxi Ganxi Prison Hospital from Jan. 2014 to Jan. 2018 were extracted to be divided into observation group and control group via the random number table,with 60 cases in each. The control group was given double eight-hedral montmorillonite powder,while the observation group was treated with sini decoction and Sishen pills. The clinical efficacy,liver function indicators[alanine aminotransferase（ ALT）,aspartate aminotransferase（ AST）,total bilirubin（ TBIL） and albumin（ ALB） ]and traditional Chinese medicine（ TCM） symptom scores of two groups were observed. RESULTS： The total effective rate of observation group was 95. 00%（ 57/60）,significantly higher than that of control group（ 78. 33%,47/60）,with statistically significant difference（ P〈0. 05）. After treatment,the levels of ALT,AST,ALB and TBIL of observation group were significantly better than those of control group,with statistically significant differences（ P〈0. 05）. After treatment, the average TCM symptom scores of observation group was（ 2. 36 ± 1. 12） points,significantly lower than that of control group [（ 7. 69 ± 1. 31） points],with statistically significant difference（ P〈0. 05）. CONCLUSIONS： The efficacy of sini decoction combined with Sishen pills in treatment of liver cirrhosis with asdthenic splenonephro-yang of intractable diarrhea is significant,which can improve patient＇s symptoms.
作者
席亨平
吴浪士
XI Hengping;WU Langshi(Dept.of Medicine of Traditional Chinese Medicine,Jiangxi Ganxi Prison Hospital,Jiangxi Gao＇ an 330800,China;Dept.of Internal Medicine,Jiangxi Ganxi Prison Hospital,Jiangxi Gao＇ an 330800,China)
出处
《中国医院用药评价与分析》
2018年第6期792-793,797,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
四逆汤合四神丸
肝硬化
脾肾阳虚型顽固性腹泻
疗效
Sini decoction combined with Sishen pills
Liver cirrhosis
Asdthenic splenonephro-yang ofintractable diarrhea
Efficacy
