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p38信号通路在三叉神经痛ION-CCI模型大鼠中的研究 被引量:4

Role of p38 signaling pathway in the trigeminal neuralgia of ION-CCI model in rats
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摘要 目的检测三叉神经痛(TN)模型大鼠三叉神经节(TG)内p-p38蛋白表达量的变化。方法采用眶下神经缩窄术(ION-CCI)制备大鼠三叉神经痛模型,将雄性SD大鼠随机分为两组,即对照组(sham组)和眶下神经缩窄术组(ION-CCI组)。Frey毛刷测定大鼠触须垫机械痛阈,Western blot检测p-p38的表达量。结果 ION-CCI组大鼠机械痛阈明显低于sham组(n=5,P<0.01)。ION-CCI组大鼠TG内p-p38的蛋白表达量均明显高于建模前正常大鼠(n=3,P<0.05)。结论 p38信号通路可能与TN的发生发展密切相关。 Objective To detect the expression of p-p38 proteins in intrigeminal ganglions( TG) of trigeminal neuralgia( TN) model in rats. Methods The TN model of rat was established by chronic constriction injury of the infraorbital never( ION-CCI). Male SD rats were randomly diviede into 2 groups: control group( sham group) and ION-CCI group. The mechanical withdrawal thresholds of vibrissa pad in two groups of rats were measured by von Frey hairs. The proteins of p-p38 in TG were detected by Western blot test. Results The mechanical thresholds of ION-CCI group were obviously lower than that in sham group( n = 5,P 〈 0. 01). The p-p38 proteins in TG of IONCCI group was over-expressed obviously after operation,which was significant different compared with that before operation( n = 3,P 〈 0. 05). Conclusion p38 signaling pathway may be closely related to the development of TN.
作者 刘雨 崔曼曼 张越 施秀芳 温泽惠 王烈成 王元银 Liu Yu;Cui Manman;Zhang Yue(Stomatological College of Anhui Medical University,Hefei 23003)
出处 《安徽医科大学学报》 CAS 北大核心 2018年第6期894-897,共4页 Acta Universitatis Medicinalis Anhui
基金 国家自然科学基金(编号:81271162) 安徽省2014年科技攻关计划项目(编号:1401045013) 合肥市自主创新政策"借转补"资金立项项目(编号:YW201608080001)
关键词 三叉神经痛 三叉神经节 眶下神经缩窄术 trigeminal neuralgia trigeminal ganglion chronic constriction injury of the infraorbital never
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