摘要
目的:观察瘿痛汤联合消肿止痛膏外敷治疗亚急性甲状腺炎热毒壅盛型的临床疗效及对复发率的影响。方法:将260例热毒壅盛型亚急性甲状腺炎患者随机分为治疗组和对照组,各130例,对照组给予强的松片治疗,治疗组给予瘿痛汤口服联合消肿止痛膏外敷双侧甲状腺,连续治疗5~7个疗程后,比较两组患者甲状腺超声图像、中医证候积分及甲状腺功能、血沉、吸碘率等指标的变化情况,评价临床疗效,随访停药后3个月、6个月的复发率。结果:两组患者治疗后甲状腺超声图像均显示肿大甲状腺恢复正常,不均匀低回声消失或明显缩小,血流信号恢复正常,其中对照组超声有效率为78.46%,治疗组超声有效率为95.38%,两组比较,差异有统计学意义(P<0.05);两组患者治疗后中医证候积分、FT3、FT4、血沉均较治疗前明显下降,TSH恢复至正常值,差异有统计学意义(P<0.01);治疗2 h、4 h、24 h后两组患者吸碘率均较治疗前显著增加,差异有统计学意义(P<0.01);治疗后治疗组有效率为93.07%,对照组为90.00%,差异无统计学意义(P>0.05)。停药后3个月、6个月随访显示,治疗组复发率均低于对照组,差异有统计学意义(P<0.05)。治疗组并发症发生率为0.70%,显著低于对照组的3.08%,两组比较,差异有统计学意义(P<0.05)。结论:瘿痛汤联合消肿止痛膏外敷治疗亚急性甲状腺炎临床疗效显著,且并发症少,复发率低。
Objective： To observe the clinical efficacy of Yingtong decoction combined with Xiaozhong Zhitong ointment on subacute thyroiditis（ SAT） with toxic heat accumulation type. Methods： 260 patients accord with the diagnostic criteria of subacute thyroiditis（ toxic heat accumulation type） were randomly divided into the treatment group and the control group. The control group was given prednisone tablets and the treatment group was treated with Yingtong decoction combined with Xiaozhong Zhitong ointment for five to seven weeks,then changes of thyroid ultrasound images,TCM syndrome scores,thyroid function,erythrocyte sedimentation rate,iodine update rate were selected to evaluate the clinical efficacy before and after treatment. Recurrence rate 3 months,6 months after withdrawal were followed up. Results： After treatment,thyroid ultrasound images showed the goiter returned to normal,and the heterogeneous hypoechoic areas disappeared or shrank,also the flow images returned to normal in the two group,and the ultrasonic efficiency in the control group was 78. 46%,and that in the treatmetn group was 95. 38%（ P 〈 0. 05）; TCM syndrome scores of two groups both decreased significantly（ P 〈 0. 01）; FT3,FT4 and erythrocyte sedimentation rate of the two groups decreased significantly than before,TSH returned to normal,Iodine absorption rate of two groups improved. The effective rate was93. 07% in the treatment group and 90. 00% in the control group,and the difference was not statistically significant（ P 〉0. 05）.Follow-up at 3 and 6 months after drug withdrawal showed that the recurrence rate of the treatment group was lower than that of the control group,and the difference was statistically significant（ P 〈 0. 05）. The incidence of complications in the treatment group was0. 70%,significantly lower than the control group＇ s 3. 08%. The difference between the two groups was statistically significant（ P 〈 0. 05）. Conclusion： The Yingtong decoction combined with Xiaozhong Zhitong ointment has significant clinical efficiency on patients with subacute thyroiditis with low complication and side effects.
作者
王伟杰
冯志海
WANG Weijie;FENG Zhihai(The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou Henan China 45000)
出处
《中医学报》
CAS
2018年第6期1119-1123,共5页
Acta Chinese Medicine
基金
河南省中医药研究专项课题项目(2016ZY2042)
关键词
亚急性甲状腺炎
热毒壅盛型
瘿痛汤
消肿止痛膏
中医药治疗
subacute thyroidities
toxic heat accumulation type
Yingtong decoction
Xiaozhong Zhitong ointment
TCM therapy
