摘要
目的观察负压伤口治疗(negative pressure wound therapy,NPWT)与敷料外敷序贯应用在糖尿病足治疗中的临床疗效。方法将2013年6月—2017年6月金湖县人民医院多学科联合诊治中心收治的46例糖尿病足患者按照随机数表法随机分为试验组(23例)与对照组(23例),其中对照组患者采用敷料外敷治疗,试验组患者采用NPWT与敷料外敷序贯治疗,对比观察两组患者的创面愈合时间、愈合效果、换药次数及治疗14 d时的创面肉芽组织覆盖率。结果试验组患者创面愈合时间为(21.80±4.73)d,对照组患者创面愈合时间为(33.80±3.75)d,两组对比采用t检验,t=9.534,P<0.01,差异具有统计学意义;试验组患者换药次数为(8.28±2.17)次,对照组患者换药次数为(19.60±3.45)次,两组对比方差不齐,采用t'检验,t'=13.320,P<0.01,差异具有统计学意义;治疗14 d时,试验组患者创面肉芽组织覆盖率为(0.91±0.10)%,对照组患者创面肉芽组织覆盖率为(0.67±0.17)%,两组对比方差不齐,采用t'检验,t'=5.836,P<0.01,差异具有统计学意义;治疗21 d时,试验组患者痊愈18例,显效4例,有效1例,总有效率为100%,对照组患者痊愈13例,显效4例,有效2例,无效4例,总有效率为82.61%,两组对比采用等级资料的秩和检验,校正u=1.827,P>0.05,差异无统计学意义。结论 NPWT与敷料外敷序贯治疗糖尿病足,可有效缩短创面愈合时间,减少换药次数,疗效显著,值得临床推广应用。
Objective To observe the clinical efficacy of the sequential application of negative pressure wound therapy（ NPWT） and dressing in the treatment of diabetic foot. Methods Forty-six diabetic foot patients admitted to the Multidiscipline Joint Diagnosis and Treatment Center of Jinhu People＇s Hospital between June 2013 and June 2017 were randomly divided into an experiment group（23 cases） and a control group（23 cases） according to the random number table. Patients in the control group were treated with the dressing while the sequential application of dressing and NPWT were given to patients in the experiment group,during which the wound healing time,healing effect,times of dressing change and the granulation tissue coverage rate on day 14 of the treatment were observed and compared. Results The wound healing times were（21. 80 ± 4. 73） d and（33. 80 ± 3. 75） d respectively in the experiment group and the control group,and the difference was statistically significant based on the t test,t = 9. 534,P〈0. 01. The times of dressing change in the experiment group was（8. 28 ± 2. 17） while（19. 60 ± 3. 45） in the control group,and t＇ test was used for their comparison due to unequal variances,which showed statistically significant difference（ t＇ = 13. 320,P〈0. 01）. The coverage rate of granulation tissues on day 14 of the treatment in the experiment group was（0. 91 ± 0. 10） % while that in the control group was（0. 67 ± 0. 17）%,and t＇ test was used for their comparison due to unequal variances,which showed statistically significant difference（ t＇ = 5. 836,P〈0. 01）. On day 21 of the treatment,in the experiment group,18 cases were cured,4 cases showed obvious effectiveness and one case showed effectiveness,with the total effective rate being 100%,while in the control group,13 cases were cured,4 cases showed obvious effectiveness,2 cases effectiveness and 4 cases ineffectiveness,with the total effective rate being 82. 61%,of which the comparison with the rank-sum test of ranked data showed no statistically significant difference,corrected u = 1. 827,P〉0. 05. Conclusion In treating diabetic foot,the sequential application of NPWT and dressing can effectively shorten the wound healing time and reduce the times of dressing change,deserving to be promoted in clinical practice.
作者
倪栋梅
Ni Dongmei(Multidiseipline Joint Diagnosis and Treatment Center of Jinhu People＇ s Hospital,Huai＇ an City,Jiangsu 2 11600,China)
出处
《中国烧伤创疡杂志》
2018年第3期162-166,共5页
The Chinese Journal of Burns Wounds & Surface Ulcers
关键词
负压伤口治疗
敷料
序贯治疗
糖尿病足
溃疡
疗效
Negative Pressure Wound Therapy
Dressing
Sequential application
Diabetic foot
Ulcer
Clinicalefficacy
