摘要
目的通过对医院儿科病房感染耐甲氧西林金黄色葡萄球菌(MRSA)的耐药性及危险因素进行分析,为MRSA儿科感染的控制提供科学依据。方法收集2015年7月至2016年6月在西南医科大学附属医院儿科临床分离的306株金黄色葡萄球菌,采用德国西门子公司MicroScan WalkAway 96SI进行菌种鉴定及药敏试验,使用WHONET5.4软件进行药敏统计分析,采用回顾调查方法对306例感染金黄色葡萄球菌患儿的临床资料进行研究,应用χ2检验和非条件Logistic回归对MRSA感染危险因素进行统计分析。结果共有90株MRSA被检测出,检出率为29.41%。MRSA主要从痰液中分离出,占74.44%;其次是血液,占10.00%。MRSA主要对阿米卡星、氨苄西林、红霉素、克林霉素等抗菌药物耐药(P<0.05)。年龄<1岁、静脉置管、机械通气、气管插管、使用呼吸机、入住ICU、住院时间>7d、使用皮质激素、低清蛋白、抗菌药物使用时间>7d是患儿感染MRSA的主要危险因素(P<0.05),其中入住NICU、静脉置管、机械通气、气管插管为独立危险因素。结论儿科病房分离的MRSA对多种抗菌药物耐药,患儿感染MRSA与多种因素相关,医院应采取相应措施,减少MRSA感染的发生。
Objective The drug resistance and risk factors of methicillin resistant Staphylococcus aureus（MRSA）infected in the pediatric ward of the hospital were analyzed to provide a scientific basis for the control of MRSA paediatric infection.Methods Totally 306 strains of Staphylococcus aureus were isolated from the pediatric wards in the Affiliated Hospital of Southwest Medical University from July 2015 to June 2016,the bacterial species identification and drug susceptibility tests were performed by MicroScan WalkAway 96 SI and the statistical analysis was carried out by WHONET5.4 softwate.The clinical data of 306 children were infected with staphylococcus aureus collected by retrospective survey,the risk factors of MRSA infection were analyzed by the method ofχ2 test and non-condition Logistic regression.Results A total of 90 strains of MRSA were detected,with a detection rate of 29.41%.MRSA was mainly isolated from sputum,accounting for74.44%,followed by blood,accounting for 10.0%.MRSA was mainly resistant to amikacin,ampicillin,erythromycin,clindamycin and other antimicrobial agents（P〈0.05）.Age〈1 years,venous catheterization,mechanical ventilation,tracheal intubation,ventilator,stay in ICU,hospitalization time 〉7 d,use of corticosteroids,low albumin,and antibiotic use time〉7 dwere the main risk factors of MRSA in children（P〈0.05）.Admission to NICU,venous catheterization,mechanical ventilation and tracheal intubation were independent risk factors.Conclusion MRSA isolated from pediatric wards is resistant to many kinds of antibiotics.Infection with MRSA is related to many factors.Hospitals should take corresponding measures to reduce the incidence of MRSA infection.
作者
魏星
丁银环
向成玉
刘恋
郑兰
刘靳波
WEI Xing;DING Yinhuan;XIANG Chengyu;LIU Lian;ZHENG Lan;LIU Jinbo(Department of Clinical Laboratory,People＇s Hospital of Pidu Area,Chengdu,Sichuan 611730,China;Department of Clinical Laboratory,the Affiliated Hospital of Southwest Medical Universit y,Luzhou,Sichuan,646000,China)
出处
《国际检验医学杂志》
CAS
2018年第11期1311-1314,共4页
International Journal of Laboratory Medicine
基金
四川省学术和技术带头人培养基金(15031)
四川大学与泸州市人民政府战略合作项目(2013CDLZ-S15)
关键词
耐甲氧西林金黄色葡萄球菌
儿科
耐药
危险因素
methicillin resistant Staphylococcus aureus
paediatrics
drug resistance
risk factors
