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铁坏死:缺血/再灌注后心肌细胞死亡的一种新方式 被引量:9

Ferroptosis: a new way of myocardial cell death after ischemia/reperfusion
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摘要 铁坏死是一种新的细胞死亡方式,受到细胞内多条信号通路严密调节,包括铁稳态调节途径、胱氨酸谷氨酸反向转运体途径和电压依赖性阴离子通道途径等。虽然有证据表明铁坏死参与了心肌缺血/再灌注损伤,但仍有许多问题尚待解决,如铁坏死主要发生在缺血/再灌注的哪个阶段?铁坏死的发生是否必须有铁离子参与?阐明铁坏死的发生过程和机制对于寻找防治心肌缺血/再灌注损伤新药具有重要意义。 Ferroptosis is a novel type of cell death,which is closely modulated by multiple signaling transduction pathways including iron homeostasis pathway,cystine/glutamate transporter( System XC-) pathway and voltage-dependent anion channel( VDAC) pathway. Although there is evidence that ferroptosis contributes to myocardial ischemia/reperfusion injury,many questions remain to be solved,such as which stage ferroptosis mainly appear following myocardial ischemia/reperfusion? Is it a necessary condition for the involvement of iron in ferroptosis? It is of significance for seeking novel drugs to protect the heart against ischemia/reperfusion injury once the mechanisms for ferroptosis are elucidated.
作者 彭军 PENG Jun(Department of Pharmacology,Xiangya School of Pharmaceutical Sciences,Central South University,Changsha,Hunan 410078,China)
出处 《中国动脉硬化杂志》 CAS 2018年第8期757-760,共4页 Chinese Journal of Arteriosclerosis
基金 国家自然科学基金项目(91439104、81373409)
关键词 铁坏死 缺血/再灌注 心肌细胞 铁稳态 ferroptosis ischemia reperfusion myocardial cell iron homeostasis
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