摘要
目的:观察头孢哌酮舒巴坦钠对淋病患者淋球菌改变及不良反应的临床效果。方法:选择2014年5月至2016年9月在本院确诊治疗的淋病患者共40例,采取随机数字表法随机均分为两组。对照组采用注射用头孢曲松钠(罗氏芬);观察组采用注射用头孢哌酮舒巴坦钠治疗。观察记录两组患者治疗临床疗效,观察记录患者不良反应发生情况,并记录比较两组患者治疗后淋球菌转阴率及患者复发率。结果:观察组患者总有效率为91.43%,显著大于对照组患者71.43%,其差异具有统计学意义(P<0.05)。两组疗效经秩和检验u=2.4132,P=0.0158。经治疗后,观察组患者不良反应总发生率为20.00%,低于对照组患者40.00%,两组患者不良反应总发生率无统计学差异(P>0.05)。观察组经治疗后第4天及第7天淋球菌转阴率分别为91.430%和97.15%;对照组经治疗后第4天及第7天淋球菌转阴率分别为74.29%和82.86%;观察组经治疗后第7天淋球菌转阴率显著高于对照组,其差异具有统计学意义(P<0.05),观察组患者复发率(2.86%)明显低于对照组(17.14%),其差异具有统计学意义(P<0.05)。结论:头孢哌酮舒巴坦钠治疗淋病患者安全有效,值得临床推广。
Objective： To observe the clinical effect of cefoperazone sulbactam sodium in treating patients with gonorrhea gonococcus and its adverse reactions. Methods： A total of 40 patients with gonorrhea diagnosed andtreated in our hospital from May 2014 to September 2016 were randomly divided into two groups. The control group using ceftriaxone sodium for injection（ Luo Shifen）,while the observation group was treated with cefoperazone sulbactam sodium for treatment. The clinical efficacy,incidence of adverse reactions,negative conversion ratio and the recurrence rate of the two groups were recorded and compared. Results： The total effective rate of the observation group was 91. 43%,which was significantly higher than that of the control group of 71. 43%（ P〈0. 05）. According to the rank sum test,the u and P value of the two groups were 2. 4132 and 0. 0158 respectively. After treatment,the incidence of adverse reactions in the observation group was 20%,which was lower than that in the control group by 40%,without statistically significant difference（ P〉0. 05）. The negative conversion ratio of gonococcus on the 4 thand 7 thday after treatment in the control group was 91. 430% and 97. 15% respectively,while those in the control group were 74. 29% and 82. 86% respectively. The negative conversion ratio of gonococcus in the observation group on the 7 thday after treatment was significantly higher than that in the control group（ P〈0. 05）. The recurrence rate in the observation group（ 2. 86%） was significantly lower than that of the control group（ 17. 14%）（ P〈0. 05）. Conclusions： The treatment of gonorrhea with cefoperazone sulbactam sodium is safe and effective,worthy of clinical promotion.
作者
夏建宇
刘佳勋
於建鹏
毛俊彪
XIA Jianyu;LIU Jiaxun;YU Jianpeng;MAO Junbiao(Department of Urology,Huangshi Aikang Hospital,Huangshi 435000,Hubei,China;Department of Urology,Huangshi Central Hospital,The Hos- pital Affiliated to Hubei Polytechnic University,Edong Medical Group,Huangshi 435000,Hubei,China)
出处
《中国性科学》
2018年第5期129-132,共4页
Chinese Journal of Human Sexuality
基金
肾脏疾病发生与干预湖北省重点实验室开放基金项目(SB201411)
关键词
头孢哌酮舒巴坦钠
淋病
淋球菌
Cefoperazone sulbaetam sodium
Gonorrhea
Neisseria gonorrhoeae
