摘要
目的探讨前列地尔联合丹红注射液治疗老年冠心病经皮冠脉介入术(PCI)患者对肾功能及血清炎性因子的影响。方法选择2016年1月—2017年6月北大医疗鲁中医院收治的老年冠心病接受PCI治疗患者80例,随机分为两组各40例。对照组给予丹红注射液静滴治疗,观察组给予前列地尔联合丹红注射液静滴治疗。PCI术后3 d,比较两组肾功能及血清炎性因子变化。结果 PCI术后3 d,观察组BUN(5.56±0.35)mmol/L、Scr(76.42±7.53)μmol/L、24HUP(186.73±20.49)mg水平低于对照组[(5.91±0.48)mmol/L、(84.63±8.68)μmol/L、(197.52±21.56)mg],差异有统计学意义(t=3.726,4.519,2.294,P<0.05);观察组TNF-α(8.12±0.53)pmol/L、IL-6(136.72±15.46)pg/m L、hs-CRP(55.34±7.23)ng/L水平低于对照组[(8.41±0.62)pmol/L、(147.28±17.53)pg/m L、(61.48±7.51)ng/L],差异有统计学意义(t=2.249,2.857,3.725,P<0.05)。结论前列地尔联合丹红注射液治疗老年冠心病PCI患者可有效保护肾功能,减轻炎症反应。
Objective To study the effect of alprostadil combined with danhong injection in treatment of senile patients with coronary heart disease PCI on the renal function and serum inflammatory factor. Methods 80 cases of senile patients with coronary heart disease PCI admitted and treated in our hospital from January 2016 to June 2017 were selected and randomly divided into two groups with 40 cases in each, the control group used the intravenous drip of danhong injection, while the observation group used the alprostadil combined with danhong injection, and the changes of renal function and serum inflammatory factor were compared between the two groups in 3 d after PCI surgery. Results The BUN, Scr, 24 HUP levels in the observation group were lower than those in the control group [（5.56±0.35） mmol/L,（76.42±7.53）μmol/L,（186.73±20.49）mg vs（5.91±0.48）mmol/L,（84.63±8.68）μmol/L,（197.52±21.56） mg], and the differences were statistically significant（t=3.726, 4.519, 2.294,P〈0.05）, and the TNF-α, IL-6 and hs-CRP in the observation group were lower than those in the control group[（8.12±0.53） pmol/L,（136.72±15.46）pg/m L,（55.34±7.23） ng/L vs（8.41±0.62）pmol/L,（147.28±17.53） pg/m L,（61.48±7.51）ng/L], and the differences were statistically significant（t=2.249, 2.857,3.725, P〈0.05）. Conclusion The alprostadil combined with danhong injection in treatment of senile patients with coronary heart disease PCI can effectively protect the renal function and relieve the inflammatory reactions.
作者
李乐胜
LI Le-sheng(Department of Cardiology,Beida Medical Luzhong Hospital,Zibo,Shandong Province,255400 China)
出处
《系统医学》
2018年第5期56-58,共3页
Systems Medicine
关键词
前列地尔
丹红注射液
老年冠心病
PCI
肾功能
血清炎性因子
Alprostadil
Danhong injection
Senile coronary heart disease
PCI
Renal function
Serum inflammatory factor
