摘要
目的对慢性心力衰竭患者血N端B型脑钠肽、β2微球蛋白的临床意义进行分析,并对其与早期肾损害的相关性进行研究。方法将2016年2月—2017年7月在该院接受诊治的90例心力衰竭患者作为该次研究的主要对象,根据患者的心功能分级情况将其分为3组,A组(心功能Ⅱ级)33例患者,B组(心功能Ⅲ级)31例患者,C组(心功能Ⅳ级)26例患者,该院对所有患者的NT-pro BNP、β2-MG、BUN和Cr进行检测,并对其进行统计学分析。结果经检验3组患者的NT--pro BNP值[(3 008.11±325.86)、(4497.48±686.52)、(5827.39±658.26)ug/L]和β2-MG值[(3.86±1.09)、(4.49±0.85)、(8.01±0.70)mg/L]经检验差异有统计学意义(P<0.01)。3组患者的BUN值和Cr值差异无统计学意义(F=0.972、0.879,P>0.05)。结论患者血N端B型脑钠肽和β2微球蛋白在慢性心力衰竭的诊断中具有重要作用,N端B型脑钠肽能够有效评估患者心功能,心力衰竭症状越严重对患者早期肾功能的损害则越严重。
Objective To analyze the clinical significance of plasma NT-pro BNP level and β2-microglobulin of patients with chronic heart failure and research the correlation with the early renal injury. Methods 90 cases of patients with heart failure diagnosed in our hospital from February 2016 to July 2017 were selected and divided into three groups according to the cardiac function classification, including 33 cases in the group A（cardiac function level Ii）, 31 cases in the group B（cardiac function level III） and 26 cases in the group C（cardiac function level IV）, and the NTpro BNP, β2-MG, BUN, Cr of all patients were tested in our hospital and statistically analyzed. Results The differences in the NT—pro BNP [（3 008.11 ±325.86）（4 497.48 ±686.52）（5 827.39 ±658.26）μg/L, β2-MG value（3.86 ±1.09）mg/L,（4.49 ±0.85）mg/L,（8.01 ±0.70）mg/L] between groups were statistically significant（P〈0.01）, and the differences in the BUN value and Cr value between groups were not obvious（F=0.972, 0.879, P〉0.05）. Conclusion The plasma NT-pro BNP level and β2-microglobulin of patients with chronic heart failure is very important, and the plasma NT-pro BNP can effectively evaluate the cardiac function, with the serious of the heart failure, the early renal injury is more serious.
作者
税国顺
SHUI Guo-shun(Department of Clinical Laboratory,Chongqing Yongrong Mining Co.,Ltd.General Hospital,Chongqing,402460 Chin)
出处
《系统医学》
2018年第7期24-25,28,共3页
Systems Medicine
关键词
慢性心力衰竭
脑钠肽
Β2微球蛋白
临床意义
相关性
Chronic heart failure
Brain natriuretic peptide
β2-microglobulin
Clinical significance
Correlation
