摘要
目的探讨丙硫氧嘧啶治疗妊娠合并甲亢的临床效果和降低药物不良反应的有效护理措施。方法将114例妊娠合并甲亢患者按其入院治疗时间顺序分为观察组和对照组,各57例。两组患者均给予常规治疗和护理;观察组在此基础上给予丙硫氧嘧啶片抗甲状腺治疗,同时针对其不良反应采取预防性护理措施。比较两组患者的治疗和护理效果。结果观察组患者妊娠结局、甲状腺功能、新生儿Apgar评分和体质量均明显优于对照组(P<0.05);观察组患者并发症发生率、新生儿早产、胎儿窘迫、新生儿甲亢的发生率均明显低于对照组(P<0.05);两组患者血细胞、肝功能异常情况比较,差异无统计学意义(P>0.05)。结论丙硫氧嘧啶治疗妊娠合并甲亢可显著改善患者的甲状腺功能,改善妊娠结局,减少患者并发症,提高新生儿体质量,降低新生儿不良反应发生率。同时,积极的护理干预可提高丙硫氧嘧啶用药安全性。
Objective To investigate the clinical effect of propylthiouracil in pregnancy complicated with hyperthyroidismand the effective nursing measures to reduce the adverse drug reactions. Methods A total of 114 pregnant women withhyperthyroidism were divided into observation group and control group according to the time sequence of admission tohospital, with 57 cases in each group. Patients in the two groups were given routine treatment and nursing, on this basis, theobservation group was given propylthiouracil, at the same time the preventive nursing measures were taken to against adversereactions. The treatment and nursing effects were compared between the two groups. Results The pregnancy outcome, thyroidfunction, neonatal Apgar score and body weight in the observation group were significantly better than those of the controlgroup （P〈0.05）. The incidence of complications of patients, premature birth, fetal distress and neonatal hyperthyroidism in theobservation group were significantly lower than those in the control group （P〈0.05）. There were no significant differences inabnormal blood cell and liver function between the two groups （P〉0.05）. Conclusion Propylthiouracil in pregnancy withhyperthyroidism can significantly improve thyroid function and pregnancy outcomes, reduce patients＇ complications, improveneonatal body mass, reduce the incidence of adverse reactions in newborns. At the same time, aggressive nursinginterventions can improve the safety of propylthiouracil.
作者
刘子娟
杨青丽
王妮
LIU Zi-juan;YANG Qing-li;WANG Ni(Obstetrics Department,Baoji Hi-tech People＇s Hospital,Baoji 721000;Obstetrics Department,Xi＇an Fourth Hospital,Xi＇an 710004,China)
出处
《临床医学研究与实践》
2018年第21期136-138,共3页
Clinical Research and Practice
