摘要
目的:探究纤维蛋白原、同型半胱氨酸与脑梗死合并动脉粥样硬化斑块患者颈动脉易损性斑块的关系。方法:选取本院2016年1月-2017年10月神经内科收治的确诊为大动脉粥样硬化型前循环区域梗死的急性脑梗死患者100例作为研究对象,根据颈血管影像学检查结果将其分为无斑块组(n=31)、稳定斑块组(n=23)、易损斑块组(n=46),并选取同时期来本院进行健康体检的同年龄层体检者50例作为对照组。比较不同组研究对象的临床资料与血液检测指标。结果:多因素Logistic回归分析结果显示男性[OR=1.408,95%CI(1.028,1.924),P=0.033]、Hcy[OR=1.014,95%CI(1.003,1.025),P=0.011]、FIB[OR=2.061,95%CI(1.340,3.170),P=0.001]、年龄[OR=1.182,95%CI(0.562,1.554),P=0.001]是急性脑梗死患者颈动脉易损性斑块危险因素。结论:纤维蛋白原、同型半胱氨酸水平与脑梗死合并动脉粥样硬化斑块患者颈动脉易损性斑块的发生呈正相关关系,对缺血性脑血管疾病风险事件的预测具有重要价值。
Objective：To investigate the relationship between fibrinogen,homocysteine and carotid artery vulnerable carotid plaques in patients with cerebral infarction and atherosclerotic plaques.Method：A total of 100 patients with acute cerebral infarction diagnosed as large artery atherosclerotic anterior circulation infarction from January 2016 to October 2017 in neurology department of our hospital were selected as study objects.According to the results of carotid angiography,they were divided into non-plaque group（n=31）,stable plaque group（n=23） and vulnerable plaque group（n=46）.50 cases of the same age who had physical examinations were selected as control group.The clinical data and the blood test indexes of different groups of subjects were compared.Result：Multivariate Logistic regression analysis showed that male [OR=1.408,95%CI（1.028,1.924）,P=0.033],Hcy [OR=1.014,95%CI（1.003, 1.025）,P=0.011],FIB[OR=2.061,95%CI（1.340,3.170）,P=0.001],age [OR=1.182,95%CI（0.562,1.554）,P=0.001] were risk factors for carotid artery vulnerable plaques in patients with acute cerebral infarction. Conclusion：Fibrinogen and homocysteine levels are positively correlated with the occurrence of carotid artery vulnerable plaque in patients with cerebral infarction and atherosclerotic plaque,and are of great value in predicting the risk events of ischemic cerebrovascular disease.
作者
钟菊
ZHONG Ju(Tongji Rehabilitation Hospital of the First People’s Hospital in Foshan City,Foshan 538000,Chin)
出处
《中国医学创新》
CAS
2018年第20期58-61,共4页
Medical Innovation of China
