摘要
目的探讨妊娠急性脂肪肝(AFLP)患者并发肺部感染的相关危险因素。方法回顾性分析2015年1月—2017年12月某三甲医院的AFLP患者的临床资料,发生肺部感染者为感染组,未发生肺部感染者为对照组,对年龄、发病孕周、发病至分娩时间、分娩方式、总胆红素(TBIL)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、血肌酐(Scr)、凝血酶原时间(PT)等进行单因素分析。结果共收集到28例AFLP患者,排除不符合纳入标准的10例患者,最终纳入18例AFLP患者,其中肺部感染组10例,对照组8例。单因素分析结果示,感染组患者血清TBIL、PT高于对照组(P<0.05),感染组患者ALT、AST水平低于对照组(P<0.05)。结论肝功能是影响AFLP患者并发肺部感染的关键因素,积极改善肝功能是防控AFLP并发肺部感染的关键。
Objective To investigate risk factors for pulmonary infection（PI） in patients with acute fatty liver of pregnancy （AFLP）. MethodsClinical data of AFLP patients in a tertiary hospital from January 2015 to December 2017 were analyzed retrospectively, patients with PI were in infection group, and those without PI were in control group. Age, gestational age at onset of PI, time from onset to delivery, mode of delivery, total bilirubin （TBIL）, alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, serum creatinine （Scr）, and prothrombin time （PT） were conducted univariate analysis. ResultsA total of 28 AFLP patients were collected, 10 patients who didn’t conform to the inclusion criteria were excluded, 18 AFLP patients were included, among whom 10 were with PI and 8 were control cases. Univariate analysis showed that serum TBIL level and PT in infection group were both higher than control group （P〈0.05）, levels of ALT and AST in infection group were lower than those in control group （P〈0.05）.ConclusionLiver function is a key factor affecting PI in patients with AFLP, improving liver function is the key to prevent and control PI in patients with AFLP.
作者
黄泽炳
陈君
漆敏
李宁
黄燕
HUANG Zebing;CHEN Jun;QI Min;LI Ning;HUANG Yan(Xiangya Hospital,Central South University,Changsha 410008,China)
出处
《中国感染控制杂志》
CAS
北大核心
2018年第8期693-696,共4页
Chinese Journal of Infection Control
基金
国家自然科学基金(81700561)
湖南省自然科学基金(2016JJ3164
2017JJ2385)
湖南省科技厅计划项目(2014SK4066)
关键词
妊娠急性脂肪肝
肺部感染
肝功能
危险因素
acute fatty liver of pregnancy
pulmonary infection
liver function
risk factor
