摘要
目的观察不同严重程度和预后的急性颅脑损伤患者血清炎性因子水平。方法方便选择2016年1月—2017年12月该院收治的110例急性颅脑损伤患者作为试验组,选择30名健康者作为对照组。比较两组及不同严重程度、不同预后患者的炎性因子水平。结果试验组血清TNF-α、IL-1β和IL-6较对照组显著升高[(138.53±13.55)mg/m L vs(42.23±5.79)mg/m L,t=9.364;(217.39±19.34)mg/L vs(113.24±10.61)mg/L,t=6.129;(58.72±7.62)pg/m L vs(15.31±1.79)pg/m L,t=5.562;P<0.05],3者水平随着创伤严重程度增加而逐级上升;且在预后不良亚组中显著高于预后良好亚组[(202.43±13.78)mg/m L vs(92.11±9.79)mg/m L,t=16.338;(283.69±20.12)mg/L vs(194.28±18.66)mg/L,t=9.551;(86.52±8.02)pg/m L vs(45.58±5.71)pg/m L,t=5.896;P<0.05]。结论监测炎性因子不但可判断急性颅脑损伤患者的病情,而且有助于评估其预后。
Objective This paper tries to investigate inflammatory mediators in patients with acute craniocerebral injury.Methods Convenient select 110 patients with acute craniocerebral injury in this hospital from January 2016 to December2017 were chosen as experimental group, and 30 healthy cases were chosen as control group. Serum inflammatory mediator were compared in two group, in subgroups according to injury severity and prognosis in patients. Results Serum TNF-α,IL-1β and IL-6 in the test group were significantly higher than those in the control group [（138.53±13.55）mg/m L vs（42.23±5.79）mg/m L, t=9.364;（217.39±19.34）mg/L vs（113.24±10.61）mg/L, t=6.129;（58.72±7.62）pg/m L vs（15.31±1.79）pg/m L, t=5.562; P〈0.05]. The three levels were severe with trauma. The degree increased gradually; and in the poor prognosis subgroup was significantly higher than the good prognosis [（202.43±13.78） mg/m L vs（92.11±9.79）mg/m L, t=16.338;（283.69±20.12）mg/L vs（194.28±18.66）mg/L, t=9.551;（86.52±8.02）pg/m L vs（45.58±5.71）pg/m L, t=5.896; P〈0.05）. Conclusion Monitoring inflammatory factors can not only judge the condition of patients with acute head injury, but also help to assess their prognosis.
作者
张欣岚
ZHA NG Xin-lan(Department of Neurosurgery,the Third People＇s Hospital Affiliated to Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian Province,350108 China)
出处
《中外医疗》
2018年第16期48-50,共3页
China & Foreign Medical Treatment
关键词
颅脑损伤
急型
炎性因子
Craniocerebral injury
Acute
Inflammatory factor
