摘要
目的探讨饮酒与颅内动脉瘤(intracranial aneurysm,IA)发病的关系。方法选取本院接诊的421例未破裂IA(unruptured intracranial aneurysm,UIA)患者为观察组和425例非IA患者作为对照组。收集研究对象的一般人口学情况、病史、行为因素和体格检查,并采集外周血3ml进行遗传易感性检测。采用孟德尔随机化方法(mendelian randomization,MR),以乙醇脱氢酶-1B基因(alcohol dehydrogenase-1B,ADH1B)的功能性突变点rs1229984作为工具变量,分析饮酒与UIA的关系。结果 ADH1B(rs1229984)的基因型在不同的年龄、性别、体型、糖尿病史、高血压史、吸烟的人群中的分布差异无统计学意义(P>0.05);基因型变异与UIA的发生比较差异无统计学意义(P>0.05);是否饮酒、不同饮酒量人群中基因型的分布差异有统计学意义(P<0.05)。因而rs1229984符合作为工具变量的条件。应用Logistic回归模型分析,结果显示是否饮酒、适量饮酒及过度饮酒与UIA无相关关系(OR=0.95~1.18,P>0.05);MR法分析结果显示与不饮酒相比,饮酒、适度饮酒、过度饮酒与IA也无相关关系(OR=0.26~4.01,P>0.05)。结论饮酒与IA的发生之间不存在具有统计学意义的关联。
Objective To explore the association between alcohol drinking and intracranial aneurysms（ IA）. Methods 421 diagnosed unruptured IA（ UIA）. and 425 controls without IA were enrolled. Information on general characteristics,diseases history,behavior, physical exam and peripheral blood were collected. The genotypes of alcohol dehydrogenase-1 B（ ADH1 B） rs1229984 were used as instrumental variables for alcohol drinking to analyze the association between alcohol drinking and UIA. Results The differences of distributions of genotypes of ADH1 B among different age,gender,body mass index（ BMI）,history of diabetes,history of hypertension and smoking status groups had no statistical significance（ P 0. 05）.No association was found between ADH1 B genotype and UIA. Alcohol drinking and consumption dose were related to GG genotypes of rs1229984（ P 0. 05）. Therefore,rs1229984 was suitable chosen as instrumental variable for alcohol drinking. According the results of the traditional logistic model,no significant associations were found between IA and drinking,moderate drinking or excessive drinking. The results of Mendelian randomization models were similar to the logistic models. Conclusions No significant association was found between alcohol drinking and IA formation.
作者
刘新志
吴新龙
许敏华
赵恒
方加胜
黄昕
LIU Xin-zhi;WU Ying-long;XU Min-hua(Department of Neurosurgery,Affliated Chinese Medicine Hospital of Xinjiang Medical University,Xinjiangg 830000,Chin)
出处
《心脑血管病防治》
2018年第3期177-180,共4页
CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
基金
湖南省自然科学基金(编号:2017JJ3215)
关键词
脑动脉瘤
饮酒
乙醇脱氢酶-1B基因
孟德尔随机化
Intracranial aneury-sm
Alcohol drinking
Alcohol dehydrogenase- 1 B
Mendelian randomization
