摘要
目的对不同妊娠期女性碘营养水平进行调查,探讨碘缺乏对孕妇及其所产新生儿甲状腺功能的影响。方法选取2016年2月至2018年2月在该院进行产前检查的妊娠女性1 628例为研究对象,检测孕妇尿碘及甲状腺功能包括甲状腺素(T_4)、三碘甲状原氨酸(T_3)、促甲状腺激素(TSH)、游离三碘甲状原氨酸(FT_3)、游离甲状腺素(FT_4);并对新生儿甲状腺功能进行筛查。结果孕早期尿碘水平为(115.3±16.8)μg/L,缺碘率为38.1%;孕中期尿碘水平为(164.8±23.4)μg/L,缺碘率为30.5%;孕晚期尿碘水平为(152.1±20.5)μg/L,缺碘率为32.6%;孕早、中、晚期碘缺乏者TSH均明显高于对照者(P<0.05),孕早期缺碘者FT_4明显低于对照者(P<0.05);不同妊娠期随着母亲尿碘水平的增加,新生儿TSH均略有降低,但差异无统计学意义(P>0.05)。结论碘缺乏会对孕妇TSH水平产生明显改变,但对其所产新生儿TSH水平影响不明显,但孕妇适当补充碘剂对改善孕妇及新生儿甲状腺功能仍具有重要意义。
Objective To investigate the iodine nutrition level of different pregnant stages women,and to explore the effect of iodine nutrition level on thyroid function of pregnant women and new born baby. Methods A total of 1 628 pregnant women enrolled in this study from February 2016 to February 2018. The urinary iodine and thyroid function of pregnant women were examined,and new born babyls thyroid function was screen. Results Urinary iodine level of early pregnancy women was （115. 3±16. 8）t,g/L,iodine deficien cy rate was 38.1 %, urinary iodine level of mid pregnancy women was （164.8 ±23.4）t,g/L, iodine deficiency rate was 30.5%,urinary iodine level of late pregnancy women was （152.1±20.5）t,g/L,iodine deficiency rate was 32.6%. TSH in early,middle and late stage of iodine deficiency patients were significantly higher than those of the controls （P〈0.05）. FT4 in pregnant women with iodine deficient in early pregnancy was signifi cantly lower than that of the controls （P〈0.05）. With the increasing of urinary iodine level,TSH of new born babies showed a decreasing trend,but there were no significant differences （P〈0.05）. Conclusion Iodine de ficiency will cause significant changes in TSH levels in pregnant women, but not significantly affect TSH level of the new born babies, but the appropriate supplementation of iodine in pregnant women is still necessary to improve the thyroid function of pregnant women and newborns.
作者
张广清
葛晶晶
苏景霞
刘玉线
杨虹英
董秋燕
ZHANG Guangqing;GE J ingjing;SU J ingxia;LIU Yuxian;YANG Hongying;DONG Qiuyan(Department of Clinical Laboratory,Maternal and Child Health Hospital of Qingyuan City,Qingyuan,Guangdong 511515,China)
出处
《检验医学与临床》
CAS
2018年第15期2276-2278,共3页
Laboratory Medicine and Clinic
关键词
碘营养
甲状腺功能
清远
孕妇
iodine nutrition
thyroid function
Qingyuan
pregnant women
